Electrochemically chalcogenative annulation enabled construction of functionalized saturated N-heterocycles

An efficient chalcogenative annulation strategy for constructing functionalized saturated N-heterocycles from unactivated alkenes with dichalcogenides under electrochemical conditions has been presented. This protocol is applicable to mono-, di- or tri-substituted alkenes, providing a straightforwar...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-09, Vol.6 (74), p.1156-1159
Main Authors: Wang, Jian, Zhao, Xinxin, Wang, Yijia, Wang, Zhihui, Zhang, Chunyan, Zong, Luyi, Li, Wenguang, Li, Ting, Chen, Ming
Format: Article
Language:English
Subjects:
Alkenes
Chemical reactions
Organic chemistry
Regioselectivity
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Summary:An efficient chalcogenative annulation strategy for constructing functionalized saturated N-heterocycles from unactivated alkenes with dichalcogenides under electrochemical conditions has been presented. This protocol is applicable to mono-, di- or tri-substituted alkenes, providing a straightforward pathway to aziridines, azetidines, pyrrolidines, and piperidines with high regioselectivity. Moreover, the strategy is qualified to realize the oxychalcogenation of alkenes as well. A highly efficient electrochemical chalcogenative annulation of unactivated alkenes to functionalized saturated N-heterocycles.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc03432e