Photocatalytic Destruction of Ceftriaxone in Aqueous Solutions

• Published in: Russian Journal of Physical Chemistry A 2024-10, Vol.98 (10), p.2241-2247
• Main Authors: Sizykh, M. R., Batoeva, A. A., Alekseev, K. D.
• Format: Article
• Language: English
• Subjects: Antibiotics; Aqueous solutions; Cephalosporins; Chemistry; Chemistry and Materials Science; Ferrous ions; Hydroxyl radicals; Oxidation; Oxidation rate; Physical Chemistry; Physical Chemistry of Solutions; Radiation; Solar radiation; Xenon lamps
• ISSN: 0036-0244; 1531-863X
• DOI: 10.1134/S0036024424701395

The kinetic tendencies in the destruction of cephalosporin antibiotics (ceftriaxone (CEF)) in photoinitiated oxidative systems were studied using a xenon lamp as a source of quasisolar radiation (UV–Vis). It was established that the oxidative systems under study can be arranged in the following series according to the efficiency and rate of antibiotic destruction: {UV–Vis/Fe 2+ /S 2 O } > {Fe 2+ /S 2 O } {UV–Vis/S 2 O } > {UV–Vis}. The optimum conditions for the oxidative destruction of CEF in the {UV–Vis/Fe 2+ /S 2 O } system are reached at [S 2 O ] : [CEF] = 30 : 1 and [S 2 O ] : [Fe 2+ ] = 1 : 0.1. As the temperature increases to 40°C, the initial CEF oxidation rate and efficiency increase. The apparent activation energy of the CEF oxidation in the {UV–Vis/Fe 2+ /S 2 O } system was 45 kJ mol –1 , which is comparable to the values obtained for cephalosporin antibiotics. It was proved, using inhibitors of radical reactions, that the oxidative destruction of CEF in combined {UV–Vis/Fe 2+ /S 2 O } proceeds by a multiradical mechanism involving reactive oxygen species (ROS): hydroxyl radicals and sulfate and superoxide radical anions. The obtained tendencies are in good agreement with the results of open-air studies with natural solar radiation; in the {Solar/Fe 2+ /S 2 O } system, the oxidation of CEF is significantly intensified due to combined activation of persulfate by the iron ions, the UV-C (