Synthesis of acyclic analogues of adenosine sulfonamides and their activity against RNA cap guanine N7-methyltransferase of SARS-CoV-2

N-Arylsulfonamide-based adenosine analogues were previously shown to be potent inhibitors of SARS-CoV-2 RNA cap guanine N7-methyltransferase nsp14. Here, we synthesized three series of N-arylsulfonamide acyclic analogues of adenosine as bisubstrates of nsp14. Most of these acyclic compounds were bar...

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Bibliographic Details
Published in:New journal of chemistry 2024-10, Vol.48 (41), p.17692-17695
Main Authors: Ahmed-Belkacem, Rostom, Delpal, Adrien, Canard, Bruno, Vasseur, Jean-Jacques, Decroly, Etienne, Debart, Françoise
Format: Article
Language:English
Subjects:
Adenosine
Sulfonamides
Online Access:Get full text
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Summary:N-Arylsulfonamide-based adenosine analogues were previously shown to be potent inhibitors of SARS-CoV-2 RNA cap guanine N7-methyltransferase nsp14. Here, we synthesized three series of N-arylsulfonamide acyclic analogues of adenosine as bisubstrates of nsp14. Most of these acyclic compounds were barely active at 50 μM against this cap N7-methyltransferase.
ISSN:1144-0546
1369-9261
DOI:10.1039/d4nj02481h