Multimaterial additive manufacturing of poly-L-lactic acid– hydroxylapatite/graphene oxide scaffold fabricated via vat photopolymerization: experimental investigation, analysis and cell study

• Published in: Rapid prototyping journal 2024-10, Vol.30 (9), p.1789-1802
• Main Authors: Ghaderi, Iman, Behravesh, Amir Hossein, Hedayati, Seyyed Kaveh, Alavinasab Ardebili, Seyed Alireza, Kordi, Omid, Rizvi, Ghaus, Gholivand, Khodayar
• Format: Article
• Language: English
• Subjects: 3-D printers; Acids; Additive manufacturing; Biological properties; Biomedical materials; Bones; Calcium phosphates; Cell growth; Composite materials; Design optimization; Glycerol; Graphene; Heat treatment; Hydroxyapatite; Linear systems; Mechanical properties; Minimal surfaces; Nanoparticles; Photopolymerization; Polylactic acid; Rapid prototyping; Resins; Scaffolds; Tissue engineering; Ultrasonic cleaning
• ISSN: 1355-2546; 1355-2546; 1758-7670
• DOI: 10.1108/RPJ-02-2024-0085

Purpose This study aims to design and implement a multimaterial system for printing multifunctional specimens suitable for various sectors, with a particular focus on biomedical applications such as addressing mandibular bone loss. Design/methodology/approach To enhance both the mechanical and biological properties of scaffolds, an automatic multimaterial setup using vat photopolymerization was developed. This setup features a linear system with two resin vats and one ultrasonic cleaning tank, facilitating the integration of diverse materials and structures to optimize scaffold composition. Such versatility allows for the simultaneous achievement of various characteristics in scaffold design. Findings The printed multimaterial scaffolds, featuring 20 Wt.% hydroxylapatite (HA) on the interior and poly-L-lactic acid (PLLA) with 1 Wt.% graphene oxide (GO) on the exterior, exhibited favorable mechanical and biological properties at the optimum postcuring and heat-treatment time. Using an edited triply periodic minimal surface (TPMS) lattice structure further enhanced these properties. Various multimaterial specimens were successfully printed and evaluated, showcasing the capability of the setup to ensure functionality, cleanliness and adequate interface bonding. Additionally, a novel Gyroid TPMS scaffold with a nominal porosity of 50% was developed and experimentally validated. Originality/value This study demonstrates the successful fabrication of multimaterial components with minimal contaminations and suitable mechanical and biological properties. By combining PLLA-HA and PLLA-GO, this innovative technique holds significant promise for enhancing the effectiveness of regenerative procedures, particularly in the realm of dentistry.