A guanidiniocarbonyl-pyrrole functionalized cucurbit[7]uril derivative as a cytomembrane disruptor for synergistic antibacterial therapy

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-11, Vol.12 (43), p.1115-1119
• Main Authors: Han, Ruixue, Du, Kehan, Li, Shengke, Zuo, Minzan, Jeyakkumar, Ponmani, Jiang, Hao, Wang, Leyong, Hu, Xiao-Yu
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibiotic resistance; Antiinfectives and antibacterials; Bacteria; Berberine; Berberine - chemistry; Berberine - pharmacology; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - pharmacology; Cell Membrane - drug effects; Drug Synergism; E coli; Escherichia coli - drug effects; Heterocyclic Compounds, 2-Ring; Imidazoles - chemistry; Imidazoles - pharmacology; Imidazolidines; Macrocyclic Compounds; Membranes; Microbial Sensitivity Tests; Molecular Structure; Pharmacology; Public health; Pyrroles - chemistry; Pyrroles - pharmacology; Staphylococcus aureus - drug effects; Strains (organisms); Supramolecular compounds
• ISSN: 2050-750X; 2050-7518
• DOI: 10.1039/d4tb01840k

The antibiotic resistance of bacterial membranes poses a significant threat to global public health, highlighting the urgent need for novel therapeutic agents and strategies to combat bacterial membranes. In response, we have developed a novel macrocyclic host molecule ( GCPCB ) based on guanidiniocarbonyl-pyrrole ( GCP ) functionalized cucurbit[7]uril with an aggregation-induced luminescence effect. GCPCB exhibits high antimicrobial potency against bacterial membranes, particularly demonstrating strong antibacterial activity against Gram-positive strains of S. aureus and Gram-negative strains of E. coli . Significantly, due to the strong binding between GCP and the bacterial membrane, GCPCB can effectively eradicate the bacteria encapsulated within. Furthermore, the formation of a host-guest complex between GCPCB and berberine hydrochloride ( BH ) not only enhances synergistic destructive activity against both species of bacteria but also provides a potential supramolecular platform for effective bacterial membrane destruction. A guanidiniocarbonyl-pyrrole functionalized cucurbit[7]uril derivative as a cytomembrane disruptor has been successfully constructed for synergistic antibacterial therapy.