Thermal analysis of tendon, cartilage and bone samples from shoulder joint replacement patients using differential scanning calorimetry (DSC) and thermogravimetry (DTA/TG)

• Published in: Journal of thermal analysis and calorimetry 2024-10, Vol.149 (20), p.11471-11483
• Main Authors: Lőrinczy, Dénes, Bata, András, Lábas, Zoltán, Shafiei, Farid, Szabó, Hajnalka, Cifra, János, Nöt, Laszlo G.
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Calcification; Cartilage; Chemistry; Chemistry and Materials Science; Collagen; Damage; Degeneration; Denaturation; Differential scanning calorimetry; Differential thermal analysis; Enthalpy; Humerus; Imaging techniques; Inorganic Chemistry; Joints (anatomy); Measurement Science and Instrumentation; Melt temperature; Orthopedics; Osteoarthritis; Parameter modification; Physical Chemistry; Polymer Sciences; Prostheses; Shoulder; Statistical analysis; Tendons; Thermal imaging; Thermodynamic properties; Thermogravimetry; Trauma
• ISSN: 1388-6150; 1588-2926
• DOI: 10.1007/s10973-023-12250-w

Despite advanced imaging techniques, more information on the extent of joint degeneration and modifications in tendon collagen content is required for selecting the appropriate type of shoulder prosthesis. The goal of this study was to compare the thermal parameters of various tissue samples from patients who had shoulder arthroplasty and to correlate the thermal shifts with the outcomes of radiological and histopathological assessments. Rotator cuff (ROC) tendon, hyaline cartilage, and subchondral bone samples were obtained throughout surgery for a comminuted 4-part proximal humerus fracture or cuff tear arthropathy. Thermal parameters were measured using differential scanning calorimetry and thermogravimetry (DTA/TG). ROC: The effect of advanced collagen damage was visible in denaturation curves of osteoarthritis samples. Only moderately increased thermal enthalpy and melting temperature were found in the tissue of the trauma patients. Cartilage: Thermal parameters revealed that structural change generated by pathologic conditions exceeded the effects of trauma. Bone: Thermal parameters from degenerative samples revealed more structural damage and calcification decrease than thermal parameters from trauma samples. Correlation: A statistically significant relationship between the extent of osteoarthritis and the thermal variables of cartilage and subchondral bone was discovered. Authors suggest that thermal analysis may be useful in the diagnostic process of orthopedic and posttraumatic shoulder diseases.