The effect of vitamin D3 supplementation on vitamin D status and associated health outcomes in children

Sufficient vitamin D status is required in childhood for normal skeletal health and the development of muscle and motor function(1). Vitamin D primarily acts through the promotion of calcium absorption from the gut and mobilisation from bone tissue(2). Childrens’ vitamin D dietary intakes are curren...

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Bibliographic Details
Published in:Proceedings of the Nutrition Society 2024-11, Vol.83 (OCE4), Article E362
Main Authors: Royle, Emily, McSorley, Emeir M., Kirsty Pourshahidi, L., Armstrong, David, Magee, Pamela J.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Age
Age groups
Calciferol
Calcium (dietary)
Calcium absorption
Calcium mobilization
Child development
Children
Childrens health
Clinical outcomes
Cognition
Cognitive ability
Diet
Dietary intake
Dietary supplements
Food
Food consumption
Food intake
Food sources
Grip strength
Health policy
Health promotion
Muscle function
Muscles
Nutrient deficiency
Parathyroid hormone
Placebos
Skeletal muscle
Vitamin D
Vitamin D3
Vitamin deficiency
Winter
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Summary:Sufficient vitamin D status is required in childhood for normal skeletal health and the development of muscle and motor function(1). Vitamin D primarily acts through the promotion of calcium absorption from the gut and mobilisation from bone tissue(2). Childrens’ vitamin D dietary intakes are currently below the recommended guidelines within the UK and Ireland suggesting a need for vitamin D3 supplementation to prevent the risk of developing vitamin D deficiency(3). The aim of this study was to examine the effect of 12 weeks’ supplementation with 10µg/d vitamin D3 vs placebo control on vitamin D status and to determine if improved vitamin D status impacted muscle function and cognition in children aged 4-11 years. In the D-VinCHI randomised, double-blind, placebo-controlled trial, healthy children (n = 118; mean age 8.1 ± 1.8 y; 51% girls) were randomly assigned to either placebo or 10µg/day of vitamin D3 for 12 weeks (year-round). Baseline and endpoint measures included anthropometric measures, hand grip strength, balance, and cognitive assessment. Blood samples were analysed for plasma 25hydroxyvitamin D [25(OH)D], and parathyroid hormone. Vitamin D consumption from food sources was assessed via a 13-item food frequency questionnaire. Following the 12-week intervention vitamin D status [25(OH)D concentration] increased in the treatment group from 66.31 ± 17.25 nmol/L to 69.04 ± 16.92 nmol/L. Change in status was significantly different compared to the placebo group within which a decrease in 25(OH)D was observed from 63.67 ± 19.48 to 56.29 ± 18.58 nmol/L, p
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665124006001