Detection of intraerythrocytic stages of malaria parasite using one-dimensional Bragg mirror optical sensor

This research focuses on the construction and analysis of a one-dimensional (1D) Bragg mirror (BM) with a micro-cavity at the centre to identify the Plasmodium falciparum parasite, which is the primary cause of malaria. In biomedical applications, early malaria identification is essential. Humans ar...

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Bibliographic Details
Published in:Journal of optics (New Delhi) 2024, Vol.53 (5), p.4961-4968
Main Authors: Gowda, Ranjith B., Gayathri, H. N., Mathias, Regina, Shreya, H. C., Veena, P. N., Raju, R. K.
Format: Article
Language:English
Subjects:
Biomedical materials
Biosensors
Crystal defects
Dimensional analysis
Erythrocytes
Lasers
Malaria
Multilayers
Optical Devices
Optical measuring instruments
Optics
Parasites
Photonic crystals
Photonics
Physics
Physics and Astronomy
Q factors
Research Article
Sensitivity
Sensors
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Summary:This research focuses on the construction and analysis of a one-dimensional (1D) Bragg mirror (BM) with a micro-cavity at the centre to identify the Plasmodium falciparum parasite, which is the primary cause of malaria. In biomedical applications, early malaria identification is essential. Humans are bitten by female Anopheles mosquitoes, which release the pathogen Plasmodium falciparum into the body. Initially invading RBCs, this parasite grows and reproduces inside human red blood cells. P. falciparum goes through a number of erythrocytic phases in the infected RBC cells. Using the appropriate diagnostic techniques, it is essential to find these infected RBC stages. Malignant cell detections can be effectively done by using 1D photonic crystal-based biosensors. A BM structure with multilayers that has been made and studied to identify the P. falciparum parasite in all of its life phases in the test sample. To increase the Q factor, the suggested structure starts with N  = 3 and concludes with N  = 6 layers. The center cavity length is altered to select the ideal defect length that improves sensitivity of the sensor. The resulted structure gives sensitivity of 4010 nm/RIU with a Q factor of 1800. Based on the simulation findings that were achieved, the suggested sensor can legitimately be employed for the early stage detection of malaria.
ISSN:0972-8821
0974-6900
DOI:10.1007/s12596-024-01669-5