Design and Synthesis of Some New Quinoxaline-Thiazole-Benzamide Hybrids: In Vitro Anticancer Activity and Their Molecular Docking Studies

Objective: The quinoxaline compound with molecular formula C 8 H 6 N 2 O, which shows a wide range of biological activities including antiviral, anticancer, antimicrobial, antituberculosis, and antileishmanial. Methods: As a part of our efforts to design new anticancer agents, in this study, we deve...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2024, Vol.50 (6), p.2171-2181
Main Authors: Dasari, Gouthami, Pandiri, Madhuri, Badithapuram, Vinitha, Karnekanti, Rajender Reddy, Mandala, Jyothi, Bandari, Srinivas
Format: Article
Language:English
Subjects:
Anticancer properties
Benzamide
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Carbonyls
Chemical synthesis
Kinases
Life Sciences
Molecular docking
Organic Chemistry
Quinoxalines
Tyrosine
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: The quinoxaline compound with molecular formula C 8 H 6 N 2 O, which shows a wide range of biological activities including antiviral, anticancer, antimicrobial, antituberculosis, and antileishmanial. Methods: As a part of our efforts to design new anticancer agents, in this study, we develop quinoxaline-thiazole-benzamide hybrids. The anticancer evolution of these hybrids was studied using the MTT assay method. Results and Discussion: The anticancer activity results exhibit that three compounds, 3,5-dimethoxy- N -(4-(2-oxo-1,2-dihydroquinoxaline-1-carbonyl)thiazol-2-yl)benzamide, 4-methoxy- N- (4-(2-oxo-1,2-dihydroquinoxa line-1-carbonyl)thiazol-2-yl)benzamide, and 3,4-dimethoxy- N -(4-(2-oxo-1,2-dihydroquinoxaline-1-carbonyl)thiazol-2-yl)benzamide were shown remarkable anticancer activity ranging from 1.23 to 1.96 µM, demonstrating greater potency than the standard drug. Conclusions: Finally, the in silico results are strongly supported by in vitro anticancer activity data and tyrosine kinase EGFR inhibitory activity assay results.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162024060104