Alkylation Reaction of Functionally Substituted 2-Hydrazine-1-carbothioamides with Some Unsaturated and Aryl Halides and Biological Activity of the Synthesized Compounds

The reaction of 2-[1-(4-methyl-5,5-R 1 ,R 2 -2-oxo-2,5-dihydrofuran-3-yl)ethylidene]­hydrazine-1-carbothioamides with allyl and propargyl bromides in the presence of a catalytic amount of sodium methylate afforded the corresponding S -derivatives. The reaction with 2-bromoacetophenone under similar...

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Bibliographic Details
Published in:Russian journal of general chemistry 2024, Vol.94 (11), p.2883-2888
Main Authors: Avetisyan, K. S., Galstyan, L. Kh
Format: Article
Language:English
Subjects:
Alkylation
Biological activity
Bromides
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Halides
Hydrazines
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Summary:The reaction of 2-[1-(4-methyl-5,5-R 1 ,R 2 -2-oxo-2,5-dihydrofuran-3-yl)ethylidene]­hydrazine-1-carbothioamides with allyl and propargyl bromides in the presence of a catalytic amount of sodium methylate afforded the corresponding S -derivatives. The reaction with 2-bromoacetophenone under similar conditions afforded the corresponding dihydrothiazoles, 5,5-disubstituted 4-methyl-3-(1-{[4-phenylthiazol-2(3 H )-ylidene]hydrazono}ethyl)furan-2(5 H )-ones. The antiradical and anticholinesterase properties of the synthesized compounds were studied. It was found that they possess moderate antiradical and high antibutyrylcholinesterase activities.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363224110082