Safety and Tolerability of Intra-Articular Injection of Adipose-Derived Mesenchymal Stem Cells GXCPC1 in 11 Subjects With Knee Osteoarthritis: A Nonrandomized Pilot Study Without a Control Arm

The current study aimed to determine the safety profile of intra-articular-injected allogeneic adipose-derived mesenchymal stem cells (ADSCs) GXCPC1 in subjects with knee osteoarthritis (OA) and its preliminary efficacy outcome. The 3 + 3 phase I study was designed with two dose-escalation cohorts:...

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Bibliographic Details
Published in:Cell transplantation 2024-01, Vol.33, p.9636897231221882
Main Authors: Chen, Cheng-Fong, Chen, Yi-Chung, Fu, Yu-Show, Tsai, Shang-Wen, Wu, Po-Kuei, Chen, Chao-Ming, Chen, Wei-Ming, Wu, Hung-Ta Hondar, Lee, Chia-Hsin, Chang, Chao-Liang, Lin, Po-Cheng, Kao, Yong-Cheng, Chen, Chun-Hung, Chuang, Ming-Hsi
Format: Article
Language:English
Subjects:
Adverse events
Humans
Injections, Intra-Articular
Knee
Mesenchymal Stem Cells
Osteoarthritis
Osteoarthritis, Knee - therapy
Pain
Pilot Projects
Stem cells
Visual perception
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