Photobiomodulation of gut microbiota with low-level laser therapy: a light for treating neuroinflammation

The gut microbiota is known to interact with various organs in the body, including the central nervous system, through the gut-brain axis. Intestinal dysbiosis can lead to increased peripheral inflammation and, consequently, affect the brain, resulting in neuroinflammation. Photobiomodulation (PBM)...

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Bibliographic Details
Published in:Lasers in medical science 2025-02, Vol.40 (1), p.64, Article 64
Main Authors: da Silva, Larissa Espindola, Martins, Daniel Fernandes, de Oliveira, Mariana Pacheco, Stenier, Mariella Reinol, Fernandes, Bruna Barros, Willemann, Stefanny da Silva, de Souza, Gabriela, Vieira, Willians Fernando, Hewitson, Andrew, Cidral-Filho, Francisco J, Rezin, Gislaine Tezza
Format: Article
Language:English
Subjects:
Brain
Central nervous system
Dentistry
Digestive system
Dysbacteriosis
Gastrointestinal tract
Homeostasis
Inflammation
Intestinal microflora
Intestine
Lasers
Literature reviews
Medicine
Medicine & Public Health
Microbiota
Microorganisms
Molecular modelling
Optical Devices
Optics
Photonics
Quantum Optics
Review
Therapy
Wound healing
Citations: Items that this one cites
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Summary:The gut microbiota is known to interact with various organs in the body, including the central nervous system, through the gut-brain axis. Intestinal dysbiosis can lead to increased peripheral inflammation and, consequently, affect the brain, resulting in neuroinflammation. Photobiomodulation (PBM) has demonstrated positive regulatory effects on the imbalance of certain body functions, including pain, inflammation, immunity, wound healing, and gut microbiota dysbiosis. Therefore, PBM at the intestinal level could help improve intestinal dysbiosis and reestablish cerebral homeostasis. In this context, this study aimed to conduct a narrative review of the literature on the effects of PBM at the intestinal level on intestinal dysbiosis and neuroinflammation. Overall, the findings highlight that PBM modulates the gut microbiota, suggesting it could serve as a therapy for neurological conditions affecting the gut-brain axis. Future research should focus on further elucidating the molecular mechanisms underlying this therapy.
ISSN:1435-604X
0268-8921
1435-604X
DOI:10.1007/s10103-025-04319-9