Novel strategies to manage CAR-T cell toxicity

The immune-related adverse events associated with chimeric antigen receptor (CAR)-T cell therapy result in substantial morbidity as well as considerable cost to the health-care system, and can limit the use of these treatments. Current therapeutic strategies to manage immune-related adverse events i...

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Bibliographic Details
Published in:Nature reviews. Drug discovery 2025-05, Vol.24 (5), p.379-397
Main Authors: Mulvey, Arthur, Trueb, Lionel, Coukos, George, Arber, Caroline
Format: Article
Language:English
Subjects:
692/4028/67/1059/153
692/4028/67/1059/2325
692/4028/67/1059/602
692/4028/67/2327
Animals
Antigens
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cancer Research
Cytokine Release Syndrome - immunology
Cytokines
Cytokines - immunology
Cytokines - metabolism
Gene therapy
Humans
Immunotherapy, Adoptive - adverse effects
Immunotherapy, Adoptive - methods
Lymphocytes
Medicinal Chemistry
Molecular Medicine
Neurotoxicity
Neurotoxicity Syndromes - immunology
Perspective
Pharmacology/Toxicology
Receptors, Chimeric Antigen - immunology
T-Lymphocytes - immunology
Toxicity
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