Buyang Huanwu Decoction Modulates the Gut Microbiota–C/EBPβ/AEP Axis to Ameliorate Cognitive Impairment in Alzheimer's Disease Mice

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and behavioral disturbances. Buyang Huanwu Decoction (BYHWD), a traditional Chinese herbal formulation, has demonstrated potential neuroprotective effects. This study aims to evalu...

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Bibliographic Details
Published in:CNS neuroscience & therapeutics 2025-06, Vol.31 (6), p.e70480-n/a
Main Authors: Liang, Junyi, Dong, Xiaohong, Yang, Jianshe, Hu, Niyuan, Luo, Xiaoting, Cong, Shuyuan, Chen, Jing, Zhao, Weiming, Liu, Bin
Format: Article
Language:English
Subjects:
AEP
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - psychology
Alzheimer's disease
Alzheimers disease
amyloid‐β
Animals
Antibiotics
Brain
Buyang Huanwu decoction
C/EBPβ
CCAAT-Enhancer-Binding Protein-beta - metabolism
Cognitive ability
Cognitive Dysfunction - drug therapy
Cognitive Dysfunction - metabolism
Drug dosages
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Fecal Microbiota Transplantation
Fecal microflora
Feces
Gastrointestinal Microbiome - drug effects
Gastrointestinal Microbiome - physiology
Gut microbiota
Gut-brain axis
Herbal medicine
Intestinal microflora
Male
Medical research
Memory
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microbiota
Neurodegenerative diseases
Neuroprotection
Neurosciences
Original
Pathogenesis
Pathology
Phosphorylation
Proteins
Signal transduction
Signal Transduction - drug effects
Tau protein
Traditional Chinese medicine
Variance analysis
β-Amyloid
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