What a tangled web we weave: crosstalk between JAK–STAT and other signalling pathways during development in Drosophila

The Janus kinase–signal transducer and activator of transcription (JAK–STAT) signalling pathway is a key player in animal development and physiology. Although it functions in a variety of processes, the net output of JAK–STAT signalling depends on its spatiotemporal activation, as well as extensive...

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Bibliographic Details
Published in:	The FEBS journal 2025-07, Vol.292 (13), p.3298-3320
Main Authors:	Mukherjee, Amartya, Anoop, Chaithra, Nongthomba, Upendra
Format:	Article
Language:	English
Subjects:	Animals Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Drosophila Drosophila - genetics Drosophila - growth & development Drosophila development Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila Proteins - genetics Drosophila Proteins - metabolism Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Fruit flies Gene Expression Regulation, Developmental Genetic analysis Growth factors Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Human disease Humans Insects Insulin - genetics Insulin - metabolism JAK–STAT Janus kinase Janus Kinases - genetics Janus Kinases - metabolism Kinases Nature conservation Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction STAT Transcription Factors - genetics STAT Transcription Factors - metabolism Tissue‐specific signalling Wnt1 Protein - genetics Wnt1 Protein - metabolism
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