Host Determinants for the Spread of Panton-Valentine Leukocidin–Positive Staphylococcus aureus in Sub-Saharan Africa

Abstract The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus can be associated with severe and recurrent skin and soft tissue infections. The prevalence of PVL is particularly high in sub-Saharan Africa. We assessed, in a multicenter cross-sectional study, whether host-related factors cou...

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Bibliographic Details
Published in:The Journal of infectious diseases 2025-11, Vol.232 (5), p.1119-1127
Main Authors: Grebe, Tobias, Rudolf, Viktoria, Gouleu, Christiane Sidonie, Adesoji, Tomiwa Olumide, Mfoutou Mapanguy, Claujens Chastel, Oladokun, Mary, Siegmund, Anke, Linh, Le Thi Kieu, Niemann, Silke, Löffler, Bettina, Adegnika, Ayola Akim, Ntoumi, Francine, Velavan, Thirumalaisamy P, Shittu, Adebayo Osagie, Schaumburg, Frieder
Format: Article
Language:English
Subjects:
Adult
Africa South of the Sahara - epidemiology
Bacterial Toxins - immunology
Cross-Sectional Studies
Cytolysis
Exotoxins - immunology
Female
Humans
IL-1β
Immune response
Immunoglobulin G
Infections
Inflammasomes
Interleukin 8
Leukocidin
Leukocidins - immunology
Leukocytes (neutrophilic)
Lymphocytes T
Male
Middle Aged
Monocytes
Monocytes - immunology
Neutrophils
Neutrophils - immunology
Prevalence
Skin
Staphylococcal Infections - epidemiology
Staphylococcal Infections - immunology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Young Adult
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