Timing of neurorehabilitation and subsequent Alzheimer's disease risk in patients with moderate to severe traumatic brain injury: A nationwide retrospective cohort study in the United States

Background Traumatic brain injury (TBI) is associated with an increased risk of Alzheimer's disease (AD). It is unknown if prompt neuro-rehabilitative treatment following moderate or severe TBI mitigates this risk compared with delayed treatment. Objective To determine whether immediate neuro-r...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2025-12, Vol.108 (3), p.1155-1165
Main Authors: Kennemer, Austin A, Gao, Zhenxiang, Davis, Pamela B, Kaelber, David C, Xu, Rong
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - epidemiology
Alzheimer Disease - etiology
Alzheimer's disease
Brain
Brain Injuries, Traumatic - complications
Brain Injuries, Traumatic - epidemiology
Brain Injuries, Traumatic - rehabilitation
Cognitive ability
Cognitive Dysfunction - epidemiology
Cohort Studies
Dementia
Dementia disorders
Female
Head injuries
Health risks
Humans
Male
Middle Aged
Neurodegenerative diseases
Neurological Rehabilitation - methods
Neurology
Rehabilitation
Retrospective Studies
Risk management
Statistical models
Time Factors
Time-to-Treatment
Traumatic brain injury
United States - epidemiology
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