ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 and its partner protein FANCI. Here, we show tha...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2020-02, Vol.8, p.2
Main Authors: Tan, Winnie, van Twest, Sylvie, Murphy, Vincent J., Deans, Andrew J.
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
Cell viability
deubiquitination
DNA repair
Enzymes
FANCD2
FANCI
Fanconi syndrome
Glycerol
Kinases
Phosphatase
Phosphorylation
Plasmids
Protease inhibitors
Proteins
Ubiquitin
Ubiquitination
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