Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling

Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide. Objective: Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, a...

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Bibliographic Details
Published in:	International journal of immunopathology and pharmacology 2025-01, Vol.39, p.3946320251318147
Main Authors:	Zhang, Nan, Wang, Wenjing, Zhang, Rongxia, Liu, Yaxuan, Wang, Yamei, Bai, Yang, Li, Chencong
Format:	Article
Language:	English
Subjects:	Animals Anti-Inflammatory Agents - pharmacology Cell Line Cells Clinical outcomes Cytokines Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium Global health Glucose Homeostasis Hospitals Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammatory diseases Invoices Kelch-Like ECH-Associated Protein 1 - metabolism Macrophages Macrophages - drug effects Macrophages - metabolism Melatonin Melatonin - pharmacology Mice Mouth Mucosa - drug effects Mouth Mucosa - metabolism Mouth Mucosa - pathology NF-E2-Related Factor 2 - metabolism Original Oxidative stress Penicillin Physiology RAW 264.7 Cells Signal transduction Signal Transduction - drug effects Tumor necrosis factor-TNF
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