SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria: A Meta-Analysis

IMPORTANCE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce chronic kidney disease (CKD) progression in individuals with type 2 diabetes, CKD, or heart failure. However, their effects in those with stage 4 CKD or little to no albuminuria remain uncertain. OBJECTIVE: To assess whether estima...

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Published in:JAMA : the journal of the American Medical Association 2026-01, Vol.335 (3), p.233-244
Main Authors: Neuen, Brendon L, Fletcher, Robert A, Anker, Stefan D, Bhatt, Deepak L, Butler, Javed, Cherney, David Z. I, Docherty, Kieran F, Inzucchi, Silvio E, Jardine, Meg J, Mahaffey, Kenneth W, McCausland, Finnian R, McGuire, Darren K, McMurray, John J. V, Neal, Bruce, Packer, Milton, Patel, Siddharth M, Perkovic, Vlado, Sabatine, Marc S, Sardell, Rebecca J, Solomon, Scott D, Vaduganathan, Muthiah, Wanner, Christoph, Wheeler, David C, Zannad, Faiez, Haynes, Richard, Staplin, Natalie, Herrington, William G, Heerspink, Hiddo J. L
Format: Article
Language:English
Subjects:
Aged
Albumins - analysis
Albuminuria - epidemiology
Albuminuria - physiopathology
Albuminuria - prevention & control
Albuminuria - urine
Antidiabetics
Clinical trials
Congestive heart failure
Creatinine
Creatinine - urine
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - urine
Disease Progression
Epidermal growth factor receptors
Failure
Female
Glomerular filtration rate
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Heart failure
Heart Failure - complications
Heart Failure - drug therapy
Humans
Inhibitors
Kidney diseases
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - prevention & control
Kidneys
Male
Meta-analysis
Middle Aged
Online First
Original Investigation
Randomized Controlled Trials as Topic
Renal failure
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - drug therapy
Renal Insufficiency, Chronic - physiopathology
Renal Insufficiency, Chronic - urine
Risk
Sodium-glucose cotransporter
Sodium-Glucose Transporter 2 Inhibitors - pharmacology
Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
Subgroups
Citations: Items that this one cites
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