Expected 8-Week Prenatal vs 12-Week Perinatal Tenofovir Alafenamide Prophylaxis to Prevent Mother-to-Child Transmission of Hepatitis B Virus: A Multicenter, Prospective, Open-Label, Randomized Controlled Trial

INTRODUCTION:The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.METHODS:In this multicenter, open-label, randomized controlled trial, eligible pregnant...

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Published in:	The American journal of gastroenterology 2025-05, Vol.120 (5), p.1045-1056
Main Authors:	Zeng, Qing-Lei, Zhou, Yi-Hua, Dong, Xiao-Ping, Zhang, Ji-Yuan, Li, Guang-Ming, Xu, Jiang-Hai, Chen, Zhi-Min, Song, Ning, Zhang, Hong-Xu, Chen, Ru-Yue, Lv, Xue-Yan, Huang, Shuo, Li, Wei-Zhe, Pan, Ya-Jie, Feng, Ying-Hua, Li, Zhi-Qin, Zhang, Guo-Fan, Lin, Wan-Bao, Zhang, Guo-Qiang, Li, Guo-Tao, Li, Wei, Zeng, Yan-Li, Zhang, Da-Wei, Cui, Guang-Lin, Lv, Jun, Liu, Yan-Min, Liang, Hong-Xia, Sun, Chang-Yu, Wang, Fu-Sheng, Yu, Zu-Jiang
Format:	Article
Language:	English
Subjects:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - therapeutic use Adult Alanine Anthropometry Antibodies Antigens Antiviral Agents - administration & dosage Antiviral Agents - therapeutic use Clinical trials Disease prevention DNA, Viral Drug dosages Female Hepatitis B Hepatitis B - prevention & control Hepatitis B - transmission Hepatitis B virus - genetics Humans Infant Infant, Newborn Infections Infectious Disease Transmission, Vertical - prevention & control Jaundice Mothers Postpartum period Pregnancy Pregnancy Complications, Infectious - drug therapy Prospective Studies Tenofovir - administration & dosage Tenofovir - analogs & derivatives Tenofovir - therapeutic use Vaccines Womens health Young Adult
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