Morphine, MDMA, MDA, and Nexus Produce a Conditioned Place Preference in Newly Hatched Chickens

The current study was undertaken to determine whether morphine and three amphetamine-related designer drugs would produce a conditioned place preference in newly hatched chickens ( Gallus gallus ). MDMA (3, 4-methylenedioxymethamphetamine) and Nexus (4-bromo-2,5-dimethoxyphenethylamine) produced a p...

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Bibliographic Details
Published in:Experimental and clinical psychopharmacology 1996-11, Vol.4 (4), p.354-362
Main Authors: Bronson, Maureen E, Wages, Theo D, Beddingfield, Thomas, Horner, Julie M, Willis, Leighia L, Scott, James L
Format: Article
Language:English
Subjects:
Amphetamines
Animal
Chickens
Methylenedioxymethamphetamine
Morphine
Place Conditioning
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Summary:The current study was undertaken to determine whether morphine and three amphetamine-related designer drugs would produce a conditioned place preference in newly hatched chickens ( Gallus gallus ). MDMA (3, 4-methylenedioxymethamphetamine) and Nexus (4-bromo-2,5-dimethoxyphenethylamine) produced a place preference at intermediate doses; MDA (3,4-methylenedioxyamphetamine) produced a place preference only at the highest dose; and morphine produced a place preference only at the lowest dose tested. A second experiment was then conducted in which the same drugs were administered outside the context of the place preference apparatus. With the exception of Nexus, none of the drugs caused in a change in preference for the initially preferred side, suggesting that the place preference seen with Nexus in Experiment 1 was of a dissociative nature (i.e., not a true conditioned place preference). Results suggest that the newly hatched chicken may be an inexpensive, alternative species for studying drug-conditioned place preferences, but the results also emphasize the importance of conducting the proper control experiments.
ISSN:1064-1297
1936-2293
DOI:10.1037/1064-1297.4.4.354