Biochemical Implications

Discusses the use of experimental animals, particularly rats, in research exploring the effectiveness of compounds such as painkillers. The author describes an experiment testing the effectiveness of a pain killer, Pentazockine. In past clinical trials, if the drug failed to produce the desired anal...

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Bibliographic Details
Published in:The American psychologist 1964-01, Vol.19 (1), p.54-54
Main Author: Frank, George H
Format: Article
Language:English
Subjects:
Analgesic Drugs
Animal
Biochemistry
Clinical Trials
Experimentation
Rats
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Description
Summary:Discusses the use of experimental animals, particularly rats, in research exploring the effectiveness of compounds such as painkillers. The author describes an experiment testing the effectiveness of a pain killer, Pentazockine. In past clinical trials, if the drug failed to produce the desired analgesic effect with the rats, further experimentation was terminated. In one particular instance, the investigators in a clinical study chose to ignore past failure of the drug on rats and tested the effect of the drug with humans--and it worked. The implications of these unexpected results on further experimentation with rats is discussed.
ISSN:0003-066X
1935-990X
DOI:10.1037/h0038456