Evaluation of Serum Insulin, Glucose, Lipid Profile, and Liver Function in [Beta]-Thalassemia Major Patients and Their Correlation With Iron Overload

The aim of this study was the evaluation of glycometabolic function, lipid profile, and liver function in patients with β thalassemia major (TM) and their relationship with serum iron and ferritin. Fasting serum glucose, insulin, cholesterol, triglyceride (TG), and liver enzymes were evaluated for 7...

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Bibliographic Details
Published in:Laboratory medicine 2010-08, Vol.41 (8), p.486
Main Authors: Shams, Sedigheh, Ashtiani, Mohammad Taghi Haghi, Monajemzadeh, Maryam, Koochakzadeh, Leili, Irani, Heshmat, Jafari, Fahimeh, Mohseni, Ameneh
Format: Article
Language:English
Subjects:
Blood diseases
Glucose
Hematology
Insulin
Lipids
Liver
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Summary:The aim of this study was the evaluation of glycometabolic function, lipid profile, and liver function in patients with β thalassemia major (TM) and their relationship with serum iron and ferritin. Fasting serum glucose, insulin, cholesterol, triglyceride (TG), and liver enzymes were evaluated for 78 homozygous TM patients and 122 normal control subjects. Serum iron, ferritin, and insulin resistance index (IRI) were determined for them. Fasting serum glucose, TG, aspartate transaminaSe (AST) levels, alanine transaminase (ALT) levels, and IRI were significantly higher in the homozygous TM patients than in the controls (P
ISSN:0007-5027