Analysis of recombination in Campylobacter jejuni from MLST population data

We analyze recombination in C. jejuni using MLST data from isolates taken from wild birds, cattle, wild rabbits, and water in a 100-km2 study region in Cheshire, UK. We use a recent approximate likelihood method for inference, based on combining likelihood information from all pairs of segregating (...

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Bibliographic Details
Published in:Journal of molecular evolution 2005-09, Vol.61 (3), p.333-340
Main Authors: Fearnhead, Paul, Smith, Nick G C, Barrigas, Mishele, Fox, Andrew, French, Nigel
Format: Article
Language:English
Subjects:
Animals
Campylobacter jejuni - genetics
Campylobacter jejuni - isolation & purification
Gene Expression Profiling
Genetic recombination
Genomics
Gram-negative bacteria
Haplotypes
Mutagenesis - genetics
Mutation
Polymorphism
Population genetics
Recombination, Genetic - genetics
Water Microbiology
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Summary:We analyze recombination in C. jejuni using MLST data from isolates taken from wild birds, cattle, wild rabbits, and water in a 100-km2 study region in Cheshire, UK. We use a recent approximate likelihood method for inference, based on combining likelihood information from all pairs of segregating (polymorphic) sites in the data. We find substantial evidence for recombination, but only for recombination with short tract lengths, of around 225-750 bp. We estimate that the rate of recombination is of a similar magnitude to the rate of mutation.
ISSN:0022-2844
1432-1432
DOI:10.1007/s00239-004-0316-0