Clinical trial showing superiority of a coconut and anise spray over permethrin 0.43% lotion for head louse infestation, ISRCTN96469780

Permethrin is the most widely used pediculicide, but evidence of resistance from several countries and anecdotal reports from Germany suggest that permethrin lotion is now less effective. We designed a randomized, controlled, parallel group trial involving 100 participants with active head louse inf...

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Bibliographic Details
Published in:European journal of pediatrics 2010, Vol.169 (1), p.55-62
Main Authors: Burgess, Ian F., Brunton, Elizabeth R., Burgess, Nazma A.
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adult
Animals
Biological and medical sciences
Child
Child, Preschool
Coconut Oil
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
General aspects
Germany
Human parasitic diseases due to arthropods
Humans
Infectious diseases
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Parasitic diseases
Pediatrics
Pediculus - drug effects
Permethrin - administration & dosage
Pimpinella
Plant Oils - administration & dosage
Plant Preparations - administration & dosage
Scalp Dermatoses - diagnosis
Scalp Dermatoses - drug therapy
Scalp Dermatoses - parasitology
Treatment Outcome
Young Adult
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Summary:Permethrin is the most widely used pediculicide, but evidence of resistance from several countries and anecdotal reports from Germany suggest that permethrin lotion is now less effective. We designed a randomized, controlled, parallel group trial involving 100 participants with active head louse infestation to investigate the activity of a coconut and anise spray and to see whether permethrin lotion is still effective, using two applications of product 9 days apart. The spray was significantly more successful (41/50, 82.0%) cures compared with permethrin (21/50, 42.0%; p  
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-009-0978-0