Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia

Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease foll...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2010-06, Vol.27 (2), p.449-453
Main Authors: Lazic, J., Tosic, N., Dokmanovic, L., Krstovski, N., Rodic, P., Pavlovic, S., Janic, D.
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Female
Follow-Up Studies
Hematology
Humans
Infant
Internal Medicine
Leukemia
Male
Medicine
Medicine & Public Health
Neoplasm Proteins - classification
Neoplasm Proteins - genetics
Oncogene Proteins, Fusion - classification
Oncogene Proteins, Fusion - genetics
Oncology
Original Paper
Pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Translocation, Genetic
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Summary:Contemporary protocols ensure high-remission rate and long-term free survival in children with acute lymphoblastic leukemia (ALL), but small percentage of patients is still incurable. Molecular genetic methods helped to establish submicroscopic classification as well as minimal residual disease follow-up, considered to be responsible for relapse. Our study enrolled 70 pediatric patients with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of four major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1). Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy with the aim to establish the correlation between chromosomal aberration, clinical features, and treatment response. Presenting the results of this study, we offer another evidence of variable incidence and clinical characteristics of ALL subtypes.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-009-9232-x