Evaluation of in vitro toxicity of Rumalaya liniment using mouse embryonic fibroblasts and human keratinocytes

The skin irritation potential of topical formulations is investigated prior to human exposure to identify the chemicals which might induce adverse skin reactions. Rumalaya liniment (RL) a novel formulation using natural oils and plant extracts is used for reducing inflammations associated with muscu...

Full description

Saved in:
Bibliographic Details
Published in:International journal of green pharmacy 2011-01, Vol.5 (1), p.1
Main Authors: Varma, SandeepRavi, Godavarthi, Ashok, Vidyashankar, Satyakumar, Nandakumar, KrishnaS, Patki, PralhadSadashiv
Format: Article
Language:English
Subjects:
Acids
Fibroblasts
Health aspects
Keratinocytes
Materia medica, Vegetable
Physiological aspects
Plant extracts
Proteins
Regression analysis
Skin
Surfactants
Toxicity
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The skin irritation potential of topical formulations is investigated prior to human exposure to identify the chemicals which might induce adverse skin reactions. Rumalaya liniment (RL) a novel formulation using natural oils and plant extracts is used for reducing inflammations associated with musculoskeletal disorders. Preclinical studies on RL are needed prior to skin application. The aim of the study was to evaluate the possible cytotoxic effects of RL and a commercial sample (CS) on mouse embryo fibroblasts and human keratinocytes using neutral red uptake, (3-(4,5- Dimethylthiazol -2-yl)-2,5-di phenyl tetrazolium bromide (MTT) and resazurin assay. The CTC 50 values obtained for RL was significantly higher than that of CS, which revealed that RL is less toxic to CS. RL was less toxic (
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.82087