Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis

Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI. To determine the association between plasma vitamin D concentrations at birth and...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2011-06, Vol.127 (6), p.e1513-e1520
Main Authors: Belderbos, Mirjam E, Houben, Michiel L, Wilbrink, Berry, Lentjes, Eef, Bloemen, Eltje M, Kimpen, Jan L L, Rovers, Maroeska, Bont, Louis
Format: Article
Language:English
Subjects:
Alfacalcidol
Babies
Bronchiolitis - blood
Bronchiolitis - complications
Bronchiolitis - virology
Calcifediol
Care and treatment
Causes of
Female
Fetal Blood - metabolism
Health aspects
Humans
Infant, Newborn
Male
Pediatrics
Pregnancy
Pregnancy Complications, Infectious
Prospective Studies
Respiratory diseases
Respiratory syncytial virus
Respiratory syncytial virus infection
Respiratory Syncytial Virus Infections - blood
Respiratory Syncytial Virus Infections - complications
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Viruses - genetics
Risk Factors
RNA, Viral - analysis
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin deficiency
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Summary:Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI. To determine the association between plasma vitamin D concentrations at birth and the subsequent risk of RSV LRTI. A prospective birth cohort study was performed in healthy term neonates. Concentrations of 25-hydroxyvitamin D (25-OHD) in cord blood plasma were related to RSV LRTI in the first year of life, defined as parent-reported LRTI symptoms in a daily log and simultaneous presence of RSV RNA in a nose-throat specimen. The study population included 156 neonates. Eighteen (12%) developed RSV LRTI. The mean plasma 25-OHD concentration was 82 nmol/L. Overall, 27% of neonates had 25-OHD concentrations < 50 nmol/L, 27% had 50-74 nmol/L and only 46% had 25-OHD 75 nmol/L. Cord blood 25-OHD concentrations were strongly associated with maternal vitamin D3 supplementation during pregnancy. Concentrations of 25-OHD were lower in neonates who subsequently developed RSV LRTI compared with those who did not (65 nmol/L versus 84 nmol/L, P = .009). Neonates born with 25-OHD concentrations
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2010-3054