Screening to prevent heart failure (STOP-HF): expanding the focus beyond asymptomatic left ventricular systolic dysfunction

Aims We evaluated the extent to which left ventricular diastolic dysfunction (LVDD) contributes to the high false‐positive rates observed when natriuretic peptides (NPs) are used to screen for left ventricular systolic dysfunction (LVSD), and the use of NPs in combination with electrocardiogram (ECG...

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Bibliographic Details
Published in:European journal of heart failure 2012-05, Vol.14 (5), p.480-486
Main Authors: Murtagh, Gillian, Dawkins, Ian R., O'Connell, Ronan, Badabhagni, Mallikarjuna, Patel, Anil, Tallon, Elaine, O'Hanlon, Rory, Ledwidge, Mark T., McDonald, Kenneth M.
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
diastolic function
ECG
Echocardiography, Doppler
Electrocardiography
False Positive Reactions
Female
heart failure
Heart Failure - diagnosis
Heart Failure - diagnostic imaging
Heart Failure - prevention & control
Humans
Male
Middle Aged
natriuretic peptide
Natriuretic Peptides - blood
Risk Factors
ROC Curve
screening
Sensitivity and Specificity
Stroke Volume
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - diagnostic imaging
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Summary:Aims We evaluated the extent to which left ventricular diastolic dysfunction (LVDD) contributes to the high false‐positive rates observed when natriuretic peptides (NPs) are used to screen for left ventricular systolic dysfunction (LVSD), and the use of NPs in combination with electrocardiogram (ECG) to screen for pre‐clinical ventricular dysfunction (PCVD). Methods and results Eight hundred and fourteen patients over 40 years of age and with at least one cardiovascular risk factor were recruited. Screening strategies for LVSD included brain natriuretic peptide (BNP) alone at cut‐offs of 20, 50, and 100 pg/mL, and BNP and abnormal ECG combined. Systolic and diastolic function was assessed by Doppler echocardiography. A left ventricular ejection fraction (LVEF) of
ISSN:1388-9842
1879-0844
DOI:10.1093/eurjhf/hfs030