Device Closure of Atrial Septal Defect: Immediate and Mid-Term Results

Background: Transcatheter closure of atrial septal defects (ASDs) has become an alternative to open surgical procedures. The Amplatzer septal occluder (ASO) has been approved since 2005 in Japan, but there are still many concerns about adverse events, and information about outcomes and complications...

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Bibliographic Details
Published in:Circulation Journal 2012, Vol.76(5), pp.1229-1234
Main Authors: Ueda, Hideaki, Yanagi, Sadamitsu, Nakamura, Hideaki, Ueno, Kentarou, Gatayama, Ryouhei, Asou, Toshihide, Yasui, Seiyo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Amplatzer septal occluder
Atrial septal defect
Catheter interventions
Catheterization - instrumentation
Catheterization - methods
Child
Child, Preschool
Complications
Female
Follow-up
Follow-Up Studies
Heart Septal Defects, Atrial - therapy
Humans
Japan
Male
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Summary:Background: Transcatheter closure of atrial septal defects (ASDs) has become an alternative to open surgical procedures. The Amplatzer septal occluder (ASO) has been approved since 2005 in Japan, but there are still many concerns about adverse events, and information about outcomes and complications is limited. The objective of this study was to assess the immediate and mid-term outcomes of device closure of secundum ASDs. Methods and Results: From August 2005 to July 2011, 208 consecutive patients with a significant secundum ASD underwent percutaneous closure with the ASO [72 males, 136 females; median age, 7.3 years (range, 3.3-21.9 years)]. Follow-up was available for 206 (99%) patients. Device closure was successful in 203 (98%) patients. Device embolization occurred in 1 case within 1h of device implantation, but the device was surgically retrieved without any neurological sequelae. During the follow-up period, complete closure was observed in 202 of 203 patients. There were no cases of erosions, late embolization, thrombus formation, or death. Conclusions: Transcatheter closure of ASDs using the ASO is safe and effective, with excellent results during mid-term follow-up. Appropriate patient selection and accurate device selection is mandatory to avoid serious complications. (Circ J 2012; 76: 1229-1234)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-11-1379