Elevated muscle enzymes and muscle biopsy in idiopathic hypoparathyroidism patients

Objective: To study idiopathic hypoparathyroidism (IHP) myopathy and its pathogenesis by histology method. Methods: We retrospectively analyzed the clinical data of nine IHP patients during the years 2006–2010. Results: We found that: 1) there was an inverse relationship between the decreased serum...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2012-03, Vol.35 (3), p.286-289
Main Authors: Dai, C. L., Sun, Z. J., Zhang, X., Qiu, M. C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biopsy
Calcium Phosphates - metabolism
Creatine Kinase - metabolism
Endocrinology
Female
Humans
Hyalin - metabolism
Hypocalcemia - metabolism
Hypocalcemia - pathology
Hypoparathyroidism - metabolism
Hypoparathyroidism - pathology
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Muscle Fibers, Skeletal - enzymology
Muscle Fibers, Skeletal - pathology
Muscle, Skeletal - enzymology
Muscle, Skeletal - pathology
Original Articles
Sarcolemma - metabolism
Vacuoles - pathology
Young Adult
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Summary:Objective: To study idiopathic hypoparathyroidism (IHP) myopathy and its pathogenesis by histology method. Methods: We retrospectively analyzed the clinical data of nine IHP patients during the years 2006–2010. Results: We found that: 1) there was an inverse relationship between the decreased serum calcium level and the elevated muscle enzymes level; 2) the IHP patients had mild-to-moderate muscle cells vacuolar degeneration and focal hyaline degeneration by hematoxylin-eosin (HE) staining; 3) except for 2 patients, the others’ muscles striations were undetectable by phosphotungstic acid hematoxylin staining; 4) 2 patients with extremely high level of creatine kinase and relatively longer disease duration had muscle atrophy, multiple focal muscle fiber hyaline degeneration and sarcolemma cells hyperplasia by HE staining; 5) all patients had different degree of immune complex deposition along the muscle cell membranes by immunofluorescence staining. Conclusion: The patients with IHP had some histological changes in skeletal muscles but with no specificity. The changes in muscles and the elevated serum muscle enzymes were related to hypocalcemia. The severity of changes in muscles was related to the duration of hypocalcemia and not only to its degree.
ISSN:0391-4097
1720-8386
DOI:10.3275/7679