Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals

Aims/hypothesis Variants of the high-mobility group A1 ( HMGA1 ) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese popu...

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Bibliographic Details
Published in:Diabetologia 2012-06, Vol.55 (6), p.1685-1688
Main Authors: Liu, L., Ding, H., Wang, H. R., Xu, Y. J., Cui, G. L., Wang, P. H., Yuan, G., Yu, X. F., Wang, D. W.
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Diabetes
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Genotype
HMGA Proteins - genetics
Human Physiology
Humans
Insulin resistance
Internal Medicine
Male
Medical records
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Polymorphism
Polymorphism, Genetic - genetics
Short Communication
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Summary:Aims/hypothesis Variants of the high-mobility group A1 ( HMGA1 ) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes. Methods Polymorphisms in HMGA1 were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls. Results We confirmed the association of the HMGA1 variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56, p  = 0.0002 under a dominant model, and 95% CI 1.16, 1.55, p  = 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%. Conclusions/interpretation HMGA1 is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-012-2518-0