Lipoid proteinosis in the eastern Mediterranean region of Turkey

Lipoid proteinosis (LP), also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease, is a rare autosomal recessive genodermatosis. Hyalin-like material is deposited in multiple organs, including the skin, oral mucosa, larynx, and brain. Only about 300 cases have been reported in the literatu...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2012-05, Vol.78 (3), p.318-322
Main Authors: Dogramaci, Asena C, Celik, Murat M, Celik, Ebru, Bayarogullari, Hanifi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biopsy
Care and treatment
Child
Consanguinity
Demographic aspects
Diagnosis
Elbow
Family
Family Health
Family medical history
Female
Genetic aspects
Humans
Laser surgery
Lipoid Proteinosis of Urbach and Wiethe - genetics
Lipoid Proteinosis of Urbach and Wiethe - pathology
Male
Mediterranean Region
Middle Aged
Siblings
Skin - pathology
Skin diseases
Turkey
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lipoid proteinosis (LP), also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease, is a rare autosomal recessive genodermatosis. Hyalin-like material is deposited in multiple organs, including the skin, oral mucosa, larynx, and brain. Only about 300 cases have been reported in the literature so far. Occurrence of LP in siblings is also rare. The reasons for relatively large number of cases, the clinical features of the patients, and the association of LP with other clinical conditions are described in this article. The aim of this study is to show that LP is not rare in Turkey and consanguineous marriage is still a social problem. We included patients between the years of 2008-2011 with lesions resembling LP. Based on the findings of clinical and histological examination of all cases, a diagnosis of LP was made. We presented six different families with multiple family members suffered from LP. In total, we determined eight children and six adult patients. Three of eight children were from the same family (sisters), the other three children belonged to another family (brothers), two children were from another family (brother and sister), and the adult patients were from three different families. Patients with LP are likely to present first to a dermatologist because of the appearance of their skin; therefore, it is important that the dermatologic diagnosis is not to be missed. We described patients with LP and discuss the salient features of this disease.
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/0378-6323.95447