Long-Term Outcomes of Percutaneous Coronary Interventions With Stent Implantation in Patients ≤40 Years Old

• Published in: The American journal of cardiology 2012-06, Vol.109 (12), p.1717-1721
• Main Authors: Meliga, Emanuele, MD, PhD, De Benedictis, Mauro, MD, Gagnor, Andrea, MD, Belli, Riccardo, MD, Scrocca, Innocenzo, MD, Lombardi, Primiano, MD, Conrotto, Federico, MD, Aranzulla, Tiziana, MD, Varbella, Ferdinando, MD, Conte, Maria Rosa, MD
• Format: Article
• Language: English
• Subjects: Adult; Angioplasty; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Cardiovascular Diseases - epidemiology; Cerebrovascular Disorders - epidemiology; Clinical outcomes; Cohort Studies; Coronary Artery Disease - mortality; Coronary Artery Disease - therapy; Diseases of the cardiovascular system; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Incidence; Male; Medical prognosis; Medical sciences; Postoperative Complications; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Registries; Retrospective Studies; Risk factors; Stents; Transplants & implants; Treatment Outcome
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2012.01.400

Data on the long-term prognosis of percutaneous coronary intervention (PCI) in young patients are limited. The aim of the present study was to report the immediate and long-term clinical outcomes in a consecutive series of young patients with premature coronary artery disease who underwent PCI with stent implantation. During the study period (2005 to 2010), 214 consecutive patients aged ≤40 years who had undergone PCI with a bare metal stent or drug-eluting stent implantation were retrospectively selected and analyzed. Primary end point of this study was the incidence of major adverse cardiac and cerebrovascular events at short- and long-term follow-up. Mean age was 36.3 ± 3.5 years and 88.3% of patients were men. Three-quarters were active smokers and all patients had ≥1 conventional cardiovascular risk factor. The total number of implanted stents was 272 (154 bare metal stent and 118 drug-eluting stent). During the hospital stay, no patient died, and the incidence of major adverse cardiac and cerebrovascular events was 2.3%. No additional events had occurred at 30 days of follow-up. At a median follow-up of 757 days (interquartile range 365 to 1,818), the overall death rate was 0.9%, and a new revascularization procedure was needed in 12.6% of patients. The major adverse cardiac and cerebrovascular event-free survival rate at the median follow-up point and 1,818 days was 89.6% and 84.2%, respectively. Active smoking and left ventricular ejection fraction