Erythrocyte n-3 Fatty Acids and Metabolic Syndrome in Middle-Aged and Older Chinese

Context: Few studies examined associations of circulating n-3 fatty acid levels with metabolic syndrome (MetS) among Chinese populations who have low consumption of these fatty acids and high risk of developing MetS. Objective: The objective of the study was to determine associations between erythro...

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Published in:The journal of clinical endocrinology and metabolism 2012-06, Vol.97 (6), p.E973-E977
Main Authors: Zhang, Geng, Sun, Qi, Hu, Frank B, Ye, Xingwang, Yu, Zhijie, Zong, Geng, Li, Huaixing, Zhou, Yunhua, Lin, Xu
Format: Article
Language:English
Subjects:
Age Distribution
Aged
alpha-Linolenic Acid - metabolism
Asian Continental Ancestry Group - statistics & numerical data
Docosahexaenoic Acids - metabolism
Eicosapentaenoic Acid - metabolism
Erythrocytes - metabolism
Fatty Acids, Omega-3 - metabolism
Fatty Acids, Unsaturated - metabolism
Female
Humans
Male
Metabolic Syndrome - ethnology
Metabolic Syndrome - metabolism
Middle Aged
Multivariate Analysis
Risk Factors
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Summary:Context: Few studies examined associations of circulating n-3 fatty acid levels with metabolic syndrome (MetS) among Chinese populations who have low consumption of these fatty acids and high risk of developing MetS. Objective: The objective of the study was to determine associations between erythrocyte n-3 fatty acids and MetS as well as its components among middle-aged and older Chinese men and women. Design and Participants: Erythrocyte levels of docosahexaenoic acid (DHA), docosapentaenoic acid, eicosapentaenoic acid, and α-linolenic acid (ALA) were measured by gas chromatography among 2754 participants aged 50–70 yr living in Beijing and Shanghai. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results: After multivariable adjustment, higher levels of DHA, but neither eicosapentaenoic acid nor docosapentaenoic acid, were associated with lower odds of MetS as well as elevated blood pressure and triglycerides. Comparing extreme quartiles of DHA, odds ratios (95% confidence interval) were 0.75 (0.55, 1.01; P for trend = 0.04) for MetS; 0.70 (0.53, 0.92; P for trend = 0.01) for elevated blood pressure; and 0.64 (0.48, 0.87; P for trend = 0.005) for elevated triglycerides. In contrast, ALA concentrations were positively associated with MetS odds (odds ratio 4.06; 95% confidence interval 2.85, 5.80; P for trend
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2011-2997