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Rapid assessment of influenza vaccine effectiveness: analysis of an internet-based cohort
The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and up...
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Published in: | Epidemiology and infection 2012-07, Vol.140 (7), p.1309-1315 |
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container_title | Epidemiology and infection |
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description | The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and uptake, we estimated vaccine effectiveness (VE) without the need for individuals to seek healthcare. We found that vaccination with the 2010 seasonal influenza vaccine was significantly protective against influenza-like illness (ILI) during the 2010–2011 influenza season (VE 52%, 95% CI 27–68). VE for individuals who received both the 2010 seasonal and 2009 pandemic influenza vaccines was 59% (95% CI 27–77), slightly higher than VE for those vaccinated in 2010 alone (VE 46%, 95% CI 9–68). Vaccinated individuals with ILI reported taking less time off work than unvaccinated individuals with ILI (3·4 days vs. 5·3 days, P |
doi_str_mv | 10.1017/S0950268811001804 |
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T. D. ; BROOKS-POLLOCK, E. ; PAOLOTTI, D. ; PEROSA, M. ; GIOANNINI, C. ; EDMUNDS, W. J.</creator><creatorcontrib>EAMES, K. T. D. ; BROOKS-POLLOCK, E. ; PAOLOTTI, D. ; PEROSA, M. ; GIOANNINI, C. ; EDMUNDS, W. J.</creatorcontrib><description>The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and uptake, we estimated vaccine effectiveness (VE) without the need for individuals to seek healthcare. We found that vaccination with the 2010 seasonal influenza vaccine was significantly protective against influenza-like illness (ILI) during the 2010–2011 influenza season (VE 52%, 95% CI 27–68). VE for individuals who received both the 2010 seasonal and 2009 pandemic influenza vaccines was 59% (95% CI 27–77), slightly higher than VE for those vaccinated in 2010 alone (VE 46%, 95% CI 9–68). Vaccinated individuals with ILI reported taking less time off work than unvaccinated individuals with ILI (3·4 days vs. 5·3 days, P<0·001).</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268811001804</identifier><identifier>PMID: 21906412</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Absenteeism ; Adolescent ; Adult ; Aged, 80 and over ; Applied microbiology ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Data Collection - methods ; Diseases ; Estimates ; Estimation methods ; Female ; Fundamental and applied biological sciences. Psychology ; Health care industry ; Health services ; Humans ; Illnesses ; Immunization ; Infant ; Infant, Newborn ; Infections ; Influenza ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - pathology ; Influenza, Human - prevention & control ; Internet ; Male ; Methods ; Microbiology ; Middle Aged ; Pandemics ; Questionnaires ; Respiratory diseases ; Seasons ; Sentinel surveillance ; Surveillance ; Symptoms ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Young Adult</subject><ispartof>Epidemiology and infection, 2012-07, Vol.140 (7), p.1309-1315</ispartof><rights>Copyright © Cambridge University Press 2011</rights><rights>Cambridge University Press 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-3695973b1dfdfc1ba01fa61165512e3869fb6c38efebd52d2d783862bdd0e06a3</citedby><cites>FETCH-LOGICAL-c501t-3695973b1dfdfc1ba01fa61165512e3869fb6c38efebd52d2d783862bdd0e06a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41549138$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0950268811001804/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,58219,58452,72709</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25963781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21906412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EAMES, K. T. D.</creatorcontrib><creatorcontrib>BROOKS-POLLOCK, E.</creatorcontrib><creatorcontrib>PAOLOTTI, D.</creatorcontrib><creatorcontrib>PEROSA, M.</creatorcontrib><creatorcontrib>GIOANNINI, C.</creatorcontrib><creatorcontrib>EDMUNDS, W. J.</creatorcontrib><title>Rapid assessment of influenza vaccine effectiveness: analysis of an internet-based cohort</title><title>Epidemiology and infection</title><addtitle>Epidemiol Infect</addtitle><description>The effectiveness of influenza vaccination programmes is seldom known during an epidemic. We developed an internet-based system to record influenza-like symptoms and response to infection in a participating cohort. Using self-reports of influenza-like symptoms and of influenza vaccine history and uptake, we estimated vaccine effectiveness (VE) without the need for individuals to seek healthcare. We found that vaccination with the 2010 seasonal influenza vaccine was significantly protective against influenza-like illness (ILI) during the 2010–2011 influenza season (VE 52%, 95% CI 27–68). VE for individuals who received both the 2010 seasonal and 2009 pandemic influenza vaccines was 59% (95% CI 27–77), slightly higher than VE for those vaccinated in 2010 alone (VE 46%, 95% CI 9–68). Vaccinated individuals with ILI reported taking less time off work than unvaccinated individuals with ILI (3·4 days vs. 5·3 days, P<0·001).</description><subject>Absenteeism</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Data Collection - methods</subject><subject>Diseases</subject><subject>Estimates</subject><subject>Estimation methods</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health care industry</subject><subject>Health services</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immunization</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - pathology</subject><subject>Influenza, Human - prevention & control</subject><subject>Internet</subject><subject>Male</subject><subject>Methods</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Questionnaires</subject><subject>Respiratory diseases</subject><subject>Seasons</subject><subject>Sentinel surveillance</subject><subject>Surveillance</subject><subject>Symptoms</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Young Adult</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqN0U2LFDEQBuAgijuu_gAPSoMIXlpT-Y43WdxVWBD8OHga0klFe-hOj0n3wvrrTTPjKorgKZD3qaKKIuQh0OdAQb_4QK2kTBkDQCkYKm6RDQhlWyGovU02a9yu-Qm5V8qOUmqZ0XfJCQNLlQC2IZ_fu30fGlcKljJimpspNn2Kw4Lpu2uunPd9wgZjRD_3V5gqe9m45Ibr0pcVu1T9jDnh3HauYGj89HXK831yJ7qh4IPje0o-nb_-ePamvXx38fbs1WXrJYW55cpKq3kHIYbooXMUolMASkpgyI2ysVOeG4zYBckCC9rUX9aFQJEqx0_Js0PffZ6-LVjm7dgXj8PgEk5L2QJl1HClLP8PCkwLoZis9MkfdDctua59UFJrAWtDOCifp1Iyxu0-96PL1xWtTm__OlGteXzsvHQjhpuKnzep4OkRuOLdELNLvi-_nLSKawPVPTq4XZmnfJMLkMICNzXnx-Hc2OU-fMHfd_jXeD8ARcuwig</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>EAMES, K. 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subjects | Absenteeism Adolescent Adult Aged, 80 and over Applied microbiology Biological and medical sciences Child Child, Preschool Cohort Studies Data Collection - methods Diseases Estimates Estimation methods Female Fundamental and applied biological sciences. Psychology Health care industry Health services Humans Illnesses Immunization Infant Infant, Newborn Infections Influenza Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - pathology Influenza, Human - prevention & control Internet Male Methods Microbiology Middle Aged Pandemics Questionnaires Respiratory diseases Seasons Sentinel surveillance Surveillance Symptoms Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Young Adult |
title | Rapid assessment of influenza vaccine effectiveness: analysis of an internet-based cohort |
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