SEOM clinical guidelines for treatment of prostate cancer

Prostate cancer (PC) is the most common cancer in men. Many patients have prolonged survival and die of other diseases, so treatment decisions are often influenced by age and coexisting comorbidities. The main procedure to diagnose PC is an ultrasound-guided core needle biopsy, which is indicated wh...

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Bibliographic Details
Published in:Clinical & translational oncology 2012-07, Vol.14 (7), p.520-527
Main Authors: Arranz Arija, José Ángel, Cassinello Espinosa, Javier, Climent Durán, Miguel Ángel, Rivera Herrero, Fernando
Format: Article
Language:English
Subjects:
Algorithms
Carcinoma - diagnosis
Carcinoma - pathology
Carcinoma - therapy
Clinical Guides in Oncology
Humans
Male
Medical Oncology - legislation & jurisprudence
Medicine
Medicine & Public Health
Neoplasm Metastasis
Neoplasm Staging - methods
Oncology
Orchiectomy - utilization
Practice Guidelines as Topic
Prostatectomy - utilization
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Spain
Treatment Failure
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Summary:Prostate cancer (PC) is the most common cancer in men. Many patients have prolonged survival and die of other diseases, so treatment decisions are often influenced by age and coexisting comorbidities. The main procedure to diagnose PC is an ultrasound-guided core needle biopsy, which is indicated when a digital rectal examination (DRE) finds nodularity or when PSA is >10 ng/ml, but is also recommended with PSA between 4.0 and 10 ng/ml. Depending on age, PSA, Gleason score and characteristics of the tumour, treatment options for localised PC are active surveillance, radical prostatectomy and radiation therapy. Androgen deprivation treatment (ADT) should be added to radiotherapy for men with intermediate- or high-risk PC. ADT is the current standard first-line treatment for metastatic PC. Castration-resistant PC is a heterogeneous entity. Several treatments such as sipuleucel-T, docetaxel-based chemotherapy, radium 223, cabazitaxel or abiraterone plus prednisone, zoledronic and denosumab, are useful for this situation.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-012-0835-x