Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models

Ribosomal stress is an important, yet poorly understood, mechanism that results in activation of the p53 tumour suppressor. We present a mutation in the ribosomal protein Rpl27a gene (sooty foot ataxia mice), isolated through a sensitized N‐ethyl‐N‐nitrosourea (ENU) mutagenesis screen for p53 pathwa...

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Bibliographic Details
Published in:	The Journal of pathology 2011-08, Vol.224 (4), p.540-552
Main Authors:	Terzian, Tamara, Dumble, Melissa, Arbab, Farinaz, Thaller, Christina, Donehower, Lawrence A, Lozano, Guillermina, Justice, Monica J, Roop, Dennis R, Box, Neil F
Format:	Article
Language:	English
Subjects:	Anemia - genetics Anemia - metabolism Animal models Animals Body Weight - genetics Bone marrow c-Kit c-Kit protein Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cerebellar ataxia Cerebellar Ataxia - genetics Cerebellar Ataxia - metabolism Cerebellar Ataxia - pathology Data processing development Disease Models, Animal Ethyl nitrosourea Foot Growth Disorders - genetics Growth Disorders - metabolism Haploinsufficiency - genetics Hematopoietic Stem Cells - pathology Hyperpigmentation Hyperpigmentation - genetics Hyperpigmentation - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Mutagenesis Mutagenicity Tests Mutation p53 p53 protein Pancytopenia Phenotype Ribosomal proteins Ribosomal Proteins - genetics Ribosomal Proteins - metabolism Ribosomal Proteins - physiology ribosomal stress Signal Transduction - physiology Stem cells Stress Transformation Tumor Suppressor Protein p53 - metabolism Tumorigenesis
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