Characterizing Compaction-Induced Thermodynamic Changes in a Common Pharmaceutical Excipient

Work, heat, and internal energy change values were measured during compression of a common pharmaceutical tablet excipient, anhydrous lactose, using a compression calorimeter. Heat of solution measurements were used independently to measure the energy change caused by compaction. Both the compressio...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2012-08, Vol.101 (8), p.2960-2967
Main Authors: Wurster, Dale Eric, Buckner, Ira S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calorimetry
compaction
compression
Drug Compounding
Excipients - chemistry
General pharmacology
Lactose - chemistry
mechanical properties
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pressure
solution calorimetry
tableting
Tablets - chemistry
Thermodynamics
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Summary:Work, heat, and internal energy change values were measured during compression of a common pharmaceutical tablet excipient, anhydrous lactose, using a compression calorimeter. Heat of solution measurements were used independently to measure the energy change caused by compaction. Both the compression calorimeter and the heat of solution measurements showed an increase in anhydrous lactose's energy state as a result of the net compression and decompression process. Excellent agreement between the energy change measured by compression calorimetry (0.94 J/g) and the energy change measured by solution calorimetry (0.91 J/g) strongly supports the data and results generated by the compression calorimeter. Furthermore, specific volume and specific surface area measurements were used to investigate the nature of the measured energy increase. The results indicate that the vast majority of the stored energy is most likely associated with residual strain within the compacted particles. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.23226