Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study

Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stor...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2012-08, Vol.38 (2), p.194-200
Main Authors: Ryu, Vin, An, Suk Kyoon, Ha, Ra Yeon, Kim, Jung Ae, Ha, Kyooseob, Cho, Hyun-Sang
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - physiopathology
Bipolar Disorder - psychology
Bipolar disorders
Cerebral Cortex - physiopathology
Electroencephalography
Evoked Potentials - physiology
Female
Humans
Male
Mania
Medical sciences
Mood disorders
N400
Neuropharmacology
Neuropsychological Tests
Pharmacology. Drug treatments
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Schizophrenia
Schizophrenia - physiopathology
Schizophrenic Psychology
Semantic priming
Word-matching task
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Summary:Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stored semantic context, which depends on the stored representation itself and the retrieval cue stimuli. The present study examines N400 components induced by a word-matching task in manic patients, and compare these responses to those induced by the task in schizophrenia and healthy controls. Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. During the task, we recorded the electroencephalogram. Reaction time analysis revealed a main effect for priming, in which reaction times were longer in response to incongruent words than to congruent words in all three participant groups (F=43.1, p
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2012.03.009