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Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study
Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stor...
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| Published in: | Progress in neuro-psychopharmacology & biological psychiatry 2012-08, Vol.38 (2), p.194-200 |
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| container_issue | 2 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Ryu, Vin An, Suk Kyoon Ha, Ra Yeon Kim, Jung Ae Ha, Kyooseob Cho, Hyun-Sang |
| description | Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stored semantic context, which depends on the stored representation itself and the retrieval cue stimuli. The present study examines N400 components induced by a word-matching task in manic patients, and compare these responses to those induced by the task in schizophrenia and healthy controls.
Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. During the task, we recorded the electroencephalogram.
Reaction time analysis revealed a main effect for priming, in which reaction times were longer in response to incongruent words than to congruent words in all three participant groups (F=43.1, p |
| doi_str_mv | 10.1016/j.pnpbp.2012.03.009 |
| format | article |
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Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. During the task, we recorded the electroencephalogram.
Reaction time analysis revealed a main effect for priming, in which reaction times were longer in response to incongruent words than to congruent words in all three participant groups (F=43.1, p<0.001) with no group effects (F=2.3, p=0.11). N400 analysis showed the main effect for priming (F=30.2, p<0.001), for group (F=5.0, p=0.01), and the interaction of priming×group (F=4.6, p=0.02). Post-hoc analysis of this interaction revealed larger N400 amplitudes to congruent words in manic patients (F=4.0, p=0.02) and smaller N400 to incongruent words in schizophrenic patients than in other groups (F=6.1, p=0.004). No correlations were found between N400 and symptom severity within patient groups.
These findings suggest that priming effects of contextually related word pairs are decreased in patients with bipolar mania, whereas priming N400 responses of contextually unrelated word pairs are increased in schizophrenia. This may be the neurophysiological evidence of abnormal automatic semantic processing in patients with bipolar mania, and it also reflects a qualitative difference in thought and speech disorders between bipolar manic and schizophrenia.
► This is the N400 study using a word-matching task. ► N400 amplitudes to related words were decreased in manic patients. ► N400 amplitudes to unrelated words were increased in schizophrenia. ► Qualitative differences in N400 responses may contribute to bipolar mania.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2012.03.009</identifier><identifier>PMID: 22504063</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - physiopathology ; Bipolar Disorder - psychology ; Bipolar disorders ; Cerebral Cortex - physiopathology ; Electroencephalography ; Evoked Potentials - physiology ; Female ; Humans ; Male ; Mania ; Medical sciences ; Mood disorders ; N400 ; Neuropharmacology ; Neuropsychological Tests ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reaction Time - physiology ; Schizophrenia ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Semantic priming ; Word-matching task</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2012-08, Vol.38 (2), p.194-200</ispartof><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d970300a784d2940c17ca1c1d300ca231824a1b37fed1138ddad7c795ed8ee783</citedby><cites>FETCH-LOGICAL-c389t-d970300a784d2940c17ca1c1d300ca231824a1b37fed1138ddad7c795ed8ee783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26141983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22504063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ryu, Vin</creatorcontrib><creatorcontrib>An, Suk Kyoon</creatorcontrib><creatorcontrib>Ha, Ra Yeon</creatorcontrib><creatorcontrib>Kim, Jung Ae</creatorcontrib><creatorcontrib>Ha, Kyooseob</creatorcontrib><creatorcontrib>Cho, Hyun-Sang</creatorcontrib><title>Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stored semantic context, which depends on the stored representation itself and the retrieval cue stimuli. The present study examines N400 components induced by a word-matching task in manic patients, and compare these responses to those induced by the task in schizophrenia and healthy controls.
Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. During the task, we recorded the electroencephalogram.
Reaction time analysis revealed a main effect for priming, in which reaction times were longer in response to incongruent words than to congruent words in all three participant groups (F=43.1, p<0.001) with no group effects (F=2.3, p=0.11). N400 analysis showed the main effect for priming (F=30.2, p<0.001), for group (F=5.0, p=0.01), and the interaction of priming×group (F=4.6, p=0.02). Post-hoc analysis of this interaction revealed larger N400 amplitudes to congruent words in manic patients (F=4.0, p=0.02) and smaller N400 to incongruent words in schizophrenic patients than in other groups (F=6.1, p=0.004). No correlations were found between N400 and symptom severity within patient groups.
These findings suggest that priming effects of contextually related word pairs are decreased in patients with bipolar mania, whereas priming N400 responses of contextually unrelated word pairs are increased in schizophrenia. This may be the neurophysiological evidence of abnormal automatic semantic processing in patients with bipolar mania, and it also reflects a qualitative difference in thought and speech disorders between bipolar manic and schizophrenia.
► This is the N400 study using a word-matching task. ► N400 amplitudes to related words were decreased in manic patients. ► N400 amplitudes to unrelated words were increased in schizophrenia. ► Qualitative differences in N400 responses may contribute to bipolar mania.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar disorders</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Electroencephalography</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mania</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>N400</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reaction Time - physiology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Semantic priming</subject><subject>Word-matching task</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxi1ERZfCEyAhX5C4bBjb2cRB4lCVv1LVXuBsTewJ9Spxgp1UWl6gr43DLnDj5PHoN9_Y38fYCwGFAFG92RdTmNqpkCBkAaoAaB6xjdC13pZSVI_ZBmSud7qsztnTlPYAIBSoJ-xcyh2UUKkNe3jvu44ihdljz7GfKeLsx8DHjuMyj0O-WZ5owLAWUxwtpeTDd-4DnyPhTI5PGcoKiWPWsmunPfDWT2OPkedJjxyD48ne-Z_jdJe3eXzLLwO_KQF4mhd3eMbOOuwTPT-dF-zbxw9frz5vr28_fbm6vN5apZt565oaFADWunSyKcGK2qKwwuWmRamEliWKVtUdOSGUdg5dbetmR04T1VpdsNdH3fyTHwul2Qw-Wep7DDQuyQiQKguX1YqqI2rjmFKkzkzRDxgPGTJrAmZvfidg1gQMKJMTyFMvTwuWdiD3d-aP5Rl4dQIwWey7iMH69I-rRCkavXLvjhxlO-49RZNsdtmS8zGbbNzo__uQX0Flpvo</recordid><startdate>20120807</startdate><enddate>20120807</enddate><creator>Ryu, Vin</creator><creator>An, Suk Kyoon</creator><creator>Ha, Ra Yeon</creator><creator>Kim, Jung Ae</creator><creator>Ha, Kyooseob</creator><creator>Cho, Hyun-Sang</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120807</creationdate><title>Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study</title><author>Ryu, Vin ; An, Suk Kyoon ; Ha, Ra Yeon ; Kim, Jung Ae ; Ha, Kyooseob ; Cho, Hyun-Sang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d970300a784d2940c17ca1c1d300ca231824a1b37fed1138ddad7c795ed8ee783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar disorders</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Electroencephalography</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mania</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>N400</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reaction Time - physiology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Semantic priming</topic><topic>Word-matching task</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ryu, Vin</creatorcontrib><creatorcontrib>An, Suk Kyoon</creatorcontrib><creatorcontrib>Ha, Ra Yeon</creatorcontrib><creatorcontrib>Kim, Jung Ae</creatorcontrib><creatorcontrib>Ha, Kyooseob</creatorcontrib><creatorcontrib>Cho, Hyun-Sang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ryu, Vin</au><au>An, Suk Kyoon</au><au>Ha, Ra Yeon</au><au>Kim, Jung Ae</au><au>Ha, Kyooseob</au><au>Cho, Hyun-Sang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2012-08-07</date><risdate>2012</risdate><volume>38</volume><issue>2</issue><spage>194</spage><epage>200</epage><pages>194-200</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Various formal thought disorders are presented as symptoms by manic patients including pressure of speech, flight of ideas, and more complex speech with strong emotional components. N400 is the event-related potential, in which amplitude is suggested to be a general index of efforts to retrieve stored semantic context, which depends on the stored representation itself and the retrieval cue stimuli. The present study examines N400 components induced by a word-matching task in manic patients, and compare these responses to those induced by the task in schizophrenia and healthy controls.
Twenty manic patients, twenty schizophrenic patients, and twenty healthy controls performed the word-matching task, in which they were presented with 120 (60 congruent and 60 incongruent) word pairs, they were instructed to discriminate whether each word pair was congruent or incongruent. During the task, we recorded the electroencephalogram.
Reaction time analysis revealed a main effect for priming, in which reaction times were longer in response to incongruent words than to congruent words in all three participant groups (F=43.1, p<0.001) with no group effects (F=2.3, p=0.11). N400 analysis showed the main effect for priming (F=30.2, p<0.001), for group (F=5.0, p=0.01), and the interaction of priming×group (F=4.6, p=0.02). Post-hoc analysis of this interaction revealed larger N400 amplitudes to congruent words in manic patients (F=4.0, p=0.02) and smaller N400 to incongruent words in schizophrenic patients than in other groups (F=6.1, p=0.004). No correlations were found between N400 and symptom severity within patient groups.
These findings suggest that priming effects of contextually related word pairs are decreased in patients with bipolar mania, whereas priming N400 responses of contextually unrelated word pairs are increased in schizophrenia. This may be the neurophysiological evidence of abnormal automatic semantic processing in patients with bipolar mania, and it also reflects a qualitative difference in thought and speech disorders between bipolar manic and schizophrenia.
► This is the N400 study using a word-matching task. ► N400 amplitudes to related words were decreased in manic patients. ► N400 amplitudes to unrelated words were increased in schizophrenia. ► Qualitative differences in N400 responses may contribute to bipolar mania.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22504063</pmid><doi>10.1016/j.pnpbp.2012.03.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Bipolar disorder Bipolar Disorder - physiopathology Bipolar Disorder - psychology Bipolar disorders Cerebral Cortex - physiopathology Electroencephalography Evoked Potentials - physiology Female Humans Male Mania Medical sciences Mood disorders N400 Neuropharmacology Neuropsychological Tests Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reaction Time - physiology Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Semantic priming Word-matching task |
| title | Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: An N400 study |
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