Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up

Experimental studies in animals and in vitro have shown the usefulness of photodynamic therapy (PDT) as an adjunct to periodontal treatment. The aim of this study was to evaluate the long-term clinical and microbiological effects of PDT associated with nonsurgical periodontal treatment. Three sites...

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Bibliographic Details
Published in:Lasers in medical science 2012-07, Vol.27 (4), p.687-693
Main Authors: Theodoro, Leticia Helena, Silva, Simoni Paro, Pires, Juliana Rico, Soares, Glaucia Helena Garcia, Pontes, Ana Emilia Farias, Zuza, Elizangela Partata, Spolidório, Denise Madalena P., de Toledo, Benedicto Egbert Correa, Garcia, Valdir Gouveia
Format: Article
Language:English
Subjects:
Adult
Combined Modality Therapy
Dental Plaque - drug therapy
Dental Plaque - microbiology
Dental Plaque - therapy
Dental Plaque Index
Dental research
Dental Scaling
Dentistry
Female
Follow-Up Studies
Gum disease
Humans
Lasers
Male
Medicine
Medicine & Public Health
Microbiology
Middle Aged
Optical Devices
Optics
Original Article
Periodontal Pocket - drug therapy
Periodontal Pocket - microbiology
Periodontal Pocket - therapy
Photochemotherapy - methods
Photodynamic therapy
Photonics
Quantum Optics
Root Planing
Treatment Outcome
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Summary:Experimental studies in animals and in vitro have shown the usefulness of photodynamic therapy (PDT) as an adjunct to periodontal treatment. The aim of this study was to evaluate the long-term clinical and microbiological effects of PDT associated with nonsurgical periodontal treatment. Three sites in each of 33 patients with chronic periodontitis were randomly allocated in a split-mouth design to a treatment group: (1) scaling and root planing (SRP group); (2) SRP and irrigation with toluidine blue O (TBO group); and (3) SRP, irrigation with TBO and low-level laser irradiation (PDT group). Clinical parameters including visible plaque index, bleeding gingival index, bleeding on probing, probing depth, gingival recession and clinical attachment level were measured at baseline, and after 60, 90 and 180 days. Additionally, subgingival plaque samples were collected for microbiological analysis by PCR. Intergroup and intragroup statistical analyses were performed. All treatment groups showed an improvement in all clinical parameters, and a significant reduction in the proportion of sites positive for periodontopathogens at 60, 90 and 180 days compared to baseline ( p   0.05). At 180 days, PDT treatment led to a significant reduction in the percentage of sites positive for all bacteria compared to SRP alone ( p  
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-011-0942-x