Apelin and Vasopressin: Two Work Better than One

Summary Water retention in the kidney is known to be an active phenomenon, controlled by a neuropeptide: vasopressin. Water excretion was assumed to be a passive phenomenon, as a result of vasopressin release blockade. This simplistic view is incorrect because water excretion is also controlled by a...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2012-07, Vol.24 (7), p.1085-1086
Main Authors: Llorens-Cortes, Catherine, Moos, Francoise
Format: Article
Language:English
Subjects:
Adult
Animals
Apelin
Biological and medical sciences
Diuretics
Drinking - genetics
Drinking - physiology
Excretion
Fundamental and applied biological sciences. Psychology
Humans
Hypothalamus
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - metabolism
Intercellular Signaling Peptides and Proteins - physiology
Kidney
Kidney - metabolism
Kidney - physiology
Models, Animal
Models, Biological
Neural Pathways - metabolism
Neural Pathways - physiology
Neurons - metabolism
Neurons - physiology
Neuropeptides
Pituitary (posterior)
Vasopressin
Vasopressins - genetics
Vasopressins - metabolism
Vasopressins - physiology
Vertebrates: endocrinology
Water-Electrolyte Balance - genetics
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Summary:Summary Water retention in the kidney is known to be an active phenomenon, controlled by a neuropeptide: vasopressin. Water excretion was assumed to be a passive phenomenon, as a result of vasopressin release blockade. This simplistic view is incorrect because water excretion is also controlled by a diuretic neuropeptide, apelin, produced not only by several peripheral tissues, but also by hypothalamic neurones, in particular the vasopressin ones projecting to the posterior pituitary.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2012.02316.x