Seasonal Changes in the Combined Glucose‐Insulin Tolerance Test in Normal Aged Horses

Background Equine metabolic syndrome (EMS) is an increasingly recognized problem in adult horses. Affected horses are often obese and predisposed to the development of laminitis, especially in the spring and summer months. In addition, in the summer and fall months, increases in endogenous insulin c...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2012-07, Vol.26 (4), p.1035-1041
Main Authors: Funk, R.A., Wooldridge, A.A., Stewart, A.J., Behrend, E.N., Kemppainen, R.J., Zhong, Q., Johnson, A.K.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - analysis
Blood Glucose - metabolism
Endocrine
Equine
Female
Glucose Tolerance Test - veterinary
Horses - metabolism
Insulin - blood
Insulin - metabolism
Male
Metabolic syndrome
Seasons
Southeastern United States
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Summary:Background Equine metabolic syndrome (EMS) is an increasingly recognized problem in adult horses. Affected horses are often obese and predisposed to the development of laminitis, especially in the spring and summer months. In addition, in the summer and fall months, increases in endogenous insulin concentrations, a marker of EMS, have been reported. Hypothesis/Objectives The purpose of this study was to evaluate seasonal changes in results of the combined glucose‐insulin tolerance test (CGIT), a diagnostic test for EMS. Animals Nine healthy, aged horses with no history of laminitis and no clinical signs of EMS. Methods Horses were given dextrose (150 mg/kg) and insulin (0.1 U/kg) IV. Plasma glucose concentrations were measured at 0, 1, 5, 15, 30, 45, 60, 75, 90, and 150 minutes and serum insulin concentrations at 0, 5, and 75 minutes. Testing was performed in February, May, June, August, September, and November. Mean glucose concentrations, characteristics of the curve, and insulin concentrations during the CGIT were compared across months using repeated measures ANOVA (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2012.00939.x