Biliopancreatic diversion induces villi elongation and cholecystokinin and ghrelin increase

Abstract Introduction Factors leading to weight loss and weight stabilization after bariatric surgery are not fully understood. Our aim was to evaluate, in Sprague–Dawley rats, the histological and gut hormonal changes after Larrad-biliopancreatic diversion (Larrad-BPD). Materials and methods Rats r...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2011-04, Vol.5 (2), p.66-70
Main Authors: Mendieta-Zerón, Hugo, Larrad-Jiménez, Álvaro, Burrell, María Angela, Rodríguez, Marina Martín, Da Boit, Katia, Frühbeck, Gema, Diéguez, Carlos
Format: Article
Language:English
Subjects:
Animals
Biliopancreatic diversion
Biliopancreatic Diversion - methods
Biliopancreatic Diversion - trends
Body Weight - physiology
Cholecystokinin - biosynthesis
Endocrinology & Metabolism
Energy Intake - physiology
Food intake
Gastric Mucosa - cytology
Gastric Mucosa - metabolism
Gastric Mucosa - physiopathology
Ghrelin - biosynthesis
Histology
Intestinal Mucosa - cytology
Intestinal Mucosa - metabolism
Intestinal Mucosa - physiopathology
Male
Rats
Rats, Sprague-Dawley
Weight
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Summary:Abstract Introduction Factors leading to weight loss and weight stabilization after bariatric surgery are not fully understood. Our aim was to evaluate, in Sprague–Dawley rats, the histological and gut hormonal changes after Larrad-biliopancreatic diversion (Larrad-BPD). Materials and methods Rats randomly underwent the following protocols: Larrad-BPD ( n = 4) versus pair fed (PF) ( n = 4). Weight and food intake were measured every day. By immunohistochemistry ghrelin was examined in the stomach, while cholecystokinin (CCK), glucagon-like-peptide-1 (GLP-1), peptide YY (PYY) and serotonin (5-HT) expression were analyzed in alimentary limb and ileum following or not the Larrad-BPD. Results Larrad-BPD rats exhibited significant ( P < 0.05) weight loss compared to PF rats. Villi enlongation was observed in Larrad-BPD rats. In residual stomach, ghrelin was diminished. In the alimentary limb, ghrelin and CCK positive cells were detected more than in the ileum of PF rats. GLP-1 expression was decreased and PYY expression was absent after Larrad-BPD compared with PF rats. Discussion Larrad-BPD is followed by histological changes and a pleiotropic gut endocrine response aimed to compensate the reduction of intestinal area exposed to food. Until now, the hormones responsible for the intestinal hypertrophy have not been defined.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2012.02.012