Association between temperament in terms of the Regulative Theory of Temperament and DRD4 and DAT1 gene polymorphisms

Abstract Objectives This is a study of the association between DRD4 exon III VNTR and DAT1 3′-untranslated region polymorphisms on the one hand and temperament assessed with the Formal Characteristics of Behaviour-Temperament Inventory on the other hand. Methods The study was run on 418 participants...

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Bibliographic Details
Published in:Comprehensive psychiatry 2012-08, Vol.53 (6), p.789-796
Main Authors: Oniszczenko, Włodzimierz, Dragan, Wojciech Ł
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Adolescent
Adult
Attention deficit hyperactivity disorder
Behavior
Biological and medical sciences
Dopamine
Dopamine Plasma Membrane Transport Proteins - genetics
Exons
Female
Gender differences
Genetic Association Studies
Genotype
Humans
Male
Medical sciences
Middle Aged
Personality - genetics
Personality Inventory
Personality traits
Polymorphism, Genetic
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Dopamine D4 - genetics
Standard deviation
Studies
Temperament
Theory
Women
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Summary:Abstract Objectives This is a study of the association between DRD4 exon III VNTR and DAT1 3′-untranslated region polymorphisms on the one hand and temperament assessed with the Formal Characteristics of Behaviour-Temperament Inventory on the other hand. Methods The study was run on 418 participants (314 women and 104 men) aged 18 to 55 years sampled from healthy male and female volunteers recruited from inhabitants of the Warsaw metropolis. Results Main effects of sex were found for briskness (F1,417 = 9.05, P = .003, η2 = 0.022), perseveration (F1,417 = 37.83, P < .001, η2 = 0.085), sensory sensitivity (F1,417 = 14.16, P < .001, η2 = 0.003), and emotional reactivity (F1,417 = 34.67, P < .001, η2 = 0.078). A significant main effect of DAT1 variant was also found for sensory sensitivity (F1,417 = 7.36, P = .007, η2 = 0.018). No main effects of DRD4 on any of the analyzed temperament traits were found. A significant interaction of sex and DRD4 variant was found for sensory sensitivity (F1,417 = 5.68, P = .018, η2 = 0.014). No significant 3-way interactions ( DAT1 × DRD4 × sex) were found. Conclusions A significant main effect of DAT1 polymorphism on sensory sensitivity and a significant interactive sex/ DRD4 effect on that same trait were found.
ISSN:0010-440X
1532-8384
DOI:10.1016/j.comppsych.2012.01.001