The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease

Abstract The intercellular adhesion molecule-1 (ICAM-1) mediates interaction of activated endothelial cells with leukocytes. It plays an important role in the pathogenesis of atherosclerosis. A functionally important polymorphism of the ICAM-1 gene, K469E, has been described. We investigated whether...

Full description

Saved in:
Bibliographic Details
Published in:Human immunology 2012-08, Vol.73 (8), p.824-828
Main Authors: Buraczynska, Monika, Zaluska, Wojciech, Baranowicz-Gaszczyk, Iwona, Buraczynska, Kinga, Niemczyk, Ewa, Ksiazek, Andrzej
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
Cardiovascular Diseases - complications
Cardiovascular Diseases - genetics
Exons
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Intercellular Adhesion Molecule-1 - genetics
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The intercellular adhesion molecule-1 (ICAM-1) mediates interaction of activated endothelial cells with leukocytes. It plays an important role in the pathogenesis of atherosclerosis. A functionally important polymorphism of the ICAM-1 gene, K469E, has been described. We investigated whether this polymorphism influences the risk of CVD in end-stage renal disease (ESRD) patients. The groups of 1016 ESRD patients and 824 healthy individuals were genotyped by PCR and allele specific oligonucleotide technique. The T allele of the K469E polymorphism was significantly more frequent in ESRD CVD+ patients than CVD− and controls (OR 2.26, 95% CI 1.87–2.72 and 1.82, 95% CI 1.55–2.11, respectively). The TT genotype was also more frequent in CVD+ patients (OR 9.90, 95% CI 6.17–15.88 vs. CVD− subgroup). When patients were stratified according to clinical outcome of CVD, there was a tendency towards higher frequencies of the T allele and TT genotype in patients with myocardial infarction (OR for T allele 1, 57, 95% CI 1.12–2.18 vs. patients without MI). In the multivariate regression analysis the carrier status of T allele of K469E was an independent risk factor of susceptibility to CVD. Our data suggest that the ICAM-1 K469E polymorphism is associated with CVD in ESRD patients.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2012.05.007