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Induced CD4+ forkhead box protein–positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1

Background Induced CD4+ forkhead box protein 3–positve regulatory T (iTreg) cells are a promising source for cell-based therapies of established inflammatory and autoimmune diseases. However, their relationship to mast cell (MC) function and MC-driven diseases remains unknown. Objective We sought to...

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Published in:Journal of allergy and clinical immunology 2012-08, Vol.130 (2), p.444-452.e7
Main Authors: Su, Wenru, MD, Fan, Huimin, MD, PhD, Chen, Maogen, MD, Wang, Julie, BS, Brand, David, PhD, He, Xiaoshun, MD, PhD, Quesniaux, Valerie, PhD, Ryffel, Bernhard, MD, PhD, Zhu, Ling, PhD, Liang, Dan, MD, PhD, Zheng, Song Guo, MD, PhD
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container_title Journal of allergy and clinical immunology
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creator Su, Wenru, MD
Fan, Huimin, MD, PhD
Chen, Maogen, MD
Wang, Julie, BS
Brand, David, PhD
He, Xiaoshun, MD, PhD
Quesniaux, Valerie, PhD
Ryffel, Bernhard, MD, PhD
Zhu, Ling, PhD
Liang, Dan, MD, PhD
Zheng, Song Guo, MD, PhD
description Background Induced CD4+ forkhead box protein 3–positve regulatory T (iTreg) cells are a promising source for cell-based therapies of established inflammatory and autoimmune diseases. However, their relationship to mast cell (MC) function and MC-driven diseases remains unknown. Objective We sought to explore the roles of iTreg cells on MC function and the established MC-driven disease contact hypersensitivity (CHS). Methods In vitro coculture studies were carried out to investigate the interaction between iTreg cells in murine or human MCs by using both direct cell-cell contact and transwell systems to separate cell-cell contact. In vivo mice iTreg cells were administered to mice with established CHS, and innate immunologic responses, such as MC infiltration and inflammatory cytokine expression at contact sites, were evaluated. Results In vitro coculture under direct cell-cell contact resulted in indirect suppression of IgE-independent activation of MCs by murine or human iTreg cells. Mechanistically, iTreg cells suppressed proinflammatory cytokine levels by modulating nuclear factor κB p65 activation in MCs through T cell–derived TGF-β1. Injection of iTreg cells but not natural CD4+ CD25+ regulatory T cells into animals with established CHS resulted in the suppression of infiltration and functions of MCs and also led to decreased production of inflammatory cytokines at allergic contact areas. iTreg cell–mediated immunosuppressive effects were abrogated when iTreg cells were pretreated with TGF-β1 small interfering RNA. Conclusions Our study demonstrates that iTreg cells suppress MC function and attenuate established MC-driven CHS through TGF-β1–dependent mechanisms.
doi_str_mv 10.1016/j.jaci.2012.05.011
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However, their relationship to mast cell (MC) function and MC-driven diseases remains unknown. Objective We sought to explore the roles of iTreg cells on MC function and the established MC-driven disease contact hypersensitivity (CHS). Methods In vitro coculture studies were carried out to investigate the interaction between iTreg cells in murine or human MCs by using both direct cell-cell contact and transwell systems to separate cell-cell contact. In vivo mice iTreg cells were administered to mice with established CHS, and innate immunologic responses, such as MC infiltration and inflammatory cytokine expression at contact sites, were evaluated. Results In vitro coculture under direct cell-cell contact resulted in indirect suppression of IgE-independent activation of MCs by murine or human iTreg cells. Mechanistically, iTreg cells suppressed proinflammatory cytokine levels by modulating nuclear factor κB p65 activation in MCs through T cell–derived TGF-β1. Injection of iTreg cells but not natural CD4+ CD25+ regulatory T cells into animals with established CHS resulted in the suppression of infiltration and functions of MCs and also led to decreased production of inflammatory cytokines at allergic contact areas. iTreg cell–mediated immunosuppressive effects were abrogated when iTreg cells were pretreated with TGF-β1 small interfering RNA. Conclusions Our study demonstrates that iTreg cells suppress MC function and attenuate established MC-driven CHS through TGF-β1–dependent mechanisms.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2012.05.011</identifier><identifier>PMID: 22738679</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>allergic ; Allergy and Immunology ; Animals ; Antigens, CD - genetics ; Antigens, CD - immunology ; Biological and medical sciences ; Cell Communication - immunology ; Coculture Techniques ; contact hypersensitivity ; Dermatitis, Contact - immunology ; Dermatitis, Contact - pathology ; Dermatitis, Contact - therapy ; Diffusion Chambers, Culture ; Disease Models, Animal ; Forkhead Transcription Factors - biosynthesis ; Forkhead Transcription Factors - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunopathology ; induced regulatory T cells ; Lymphocyte Activation ; Lymphocyte Transfusion ; Mast cells ; Mast Cells - immunology ; Mast Cells - metabolism ; Medical sciences ; Mice ; Mice, Inbred BALB C ; NF-kappa B - genetics ; NF-kappa B - immunology ; RNA, Small Interfering - genetics ; RNA, Small Interfering - immunology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Signal Transduction - immunology ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; TGF-β ; Transforming Growth Factor beta1 - antagonists &amp; inhibitors ; Transforming Growth Factor beta1 - immunology</subject><ispartof>Journal of allergy and clinical immunology, 2012-08, Vol.130 (2), p.444-452.e7</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Published by Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6a8f6a0cff369022af83f2fe2f3fd1aa22a6706a2c71136c498e04500b5ca1593</citedby><cites>FETCH-LOGICAL-c356t-6a8f6a0cff369022af83f2fe2f3fd1aa22a6706a2c71136c498e04500b5ca1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=26250035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22738679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Wenru, MD</creatorcontrib><creatorcontrib>Fan, Huimin, MD, PhD</creatorcontrib><creatorcontrib>Chen, Maogen, MD</creatorcontrib><creatorcontrib>Wang, Julie, BS</creatorcontrib><creatorcontrib>Brand, David, PhD</creatorcontrib><creatorcontrib>He, Xiaoshun, MD, PhD</creatorcontrib><creatorcontrib>Quesniaux, Valerie, PhD</creatorcontrib><creatorcontrib>Ryffel, Bernhard, MD, PhD</creatorcontrib><creatorcontrib>Zhu, Ling, PhD</creatorcontrib><creatorcontrib>Liang, Dan, MD, PhD</creatorcontrib><creatorcontrib>Zheng, Song Guo, MD, PhD</creatorcontrib><title>Induced CD4+ forkhead box protein–positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Induced CD4+ forkhead box protein 3–positve regulatory T (iTreg) cells are a promising source for cell-based therapies of established inflammatory and autoimmune diseases. However, their relationship to mast cell (MC) function and MC-driven diseases remains unknown. Objective We sought to explore the roles of iTreg cells on MC function and the established MC-driven disease contact hypersensitivity (CHS). Methods In vitro coculture studies were carried out to investigate the interaction between iTreg cells in murine or human MCs by using both direct cell-cell contact and transwell systems to separate cell-cell contact. In vivo mice iTreg cells were administered to mice with established CHS, and innate immunologic responses, such as MC infiltration and inflammatory cytokine expression at contact sites, were evaluated. Results In vitro coculture under direct cell-cell contact resulted in indirect suppression of IgE-independent activation of MCs by murine or human iTreg cells. Mechanistically, iTreg cells suppressed proinflammatory cytokine levels by modulating nuclear factor κB p65 activation in MCs through T cell–derived TGF-β1. Injection of iTreg cells but not natural CD4+ CD25+ regulatory T cells into animals with established CHS resulted in the suppression of infiltration and functions of MCs and also led to decreased production of inflammatory cytokines at allergic contact areas. iTreg cell–mediated immunosuppressive effects were abrogated when iTreg cells were pretreated with TGF-β1 small interfering RNA. Conclusions Our study demonstrates that iTreg cells suppress MC function and attenuate established MC-driven CHS through TGF-β1–dependent mechanisms.</description><subject>allergic</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Communication - immunology</subject><subject>Coculture Techniques</subject><subject>contact hypersensitivity</subject><subject>Dermatitis, Contact - immunology</subject><subject>Dermatitis, Contact - pathology</subject><subject>Dermatitis, Contact - therapy</subject><subject>Diffusion Chambers, Culture</subject><subject>Disease Models, Animal</subject><subject>Forkhead Transcription Factors - biosynthesis</subject><subject>Forkhead Transcription Factors - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>induced regulatory T cells</subject><subject>Lymphocyte Activation</subject><subject>Lymphocyte Transfusion</subject><subject>Mast cells</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>NF-kappa B - genetics</subject><subject>NF-kappa B - immunology</subject><subject>RNA, Small Interfering - genetics</subject><subject>RNA, Small Interfering - immunology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Signal Transduction - immunology</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - metabolism</subject><subject>TGF-β</subject><subject>Transforming Growth Factor beta1 - antagonists &amp; inhibitors</subject><subject>Transforming Growth Factor beta1 - immunology</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9ksGK1TAUhosoznX0BVxINoIgrSdJm7YgA3J1xoEBF17XIU0Tm05vck3Swbtz6d438UF8CJ_EdO5VwYWrkPD9f845_8myxxgKDJi9GItRSFMQwKSAqgCM72QrDG2ds4ZUd7MVQItzVpftSfYghBHSnTbt_eyEkJo2rG5X2ddL289S9Wj9unyOtPPXgxI96txntPMuKmN_fvm2c8FEc6PQBkk1TQEZO5jORLQVId4-IT1bGY2zSNgeqRBFN5kwJF_pbBQyomG_Uz4oe-tk4h7Fwbv544A2F-f5j-_4YXZPiymoR8fzNPtw_mazfptfvbu4XL-6yiWtWMyZaDQTILWmrAVChG6oJloRTXWPhUgvrAYmiKwxpkyWbaOgrAC6SgpctfQ0e3bwTe19mlOlfGvC0oKwys2BY6BQQckIJJQcUOldCF5pvvNmK_w-QXxJgI98SYAvCXCoeEogiZ4c_eduq_o_kt8jT8DTIyCCFJP2wkoT_nKMpGpplbiXB06ladwY5XmQRtmUlfFKRt478_86zv6Ry8lYk368VnsVRjd7m-bMMQ9Jw98vu7KsCiYAddMC_QXgJbv2</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Su, Wenru, MD</creator><creator>Fan, Huimin, MD, PhD</creator><creator>Chen, Maogen, MD</creator><creator>Wang, Julie, BS</creator><creator>Brand, David, PhD</creator><creator>He, Xiaoshun, MD, PhD</creator><creator>Quesniaux, Valerie, PhD</creator><creator>Ryffel, Bernhard, MD, PhD</creator><creator>Zhu, Ling, PhD</creator><creator>Liang, Dan, MD, PhD</creator><creator>Zheng, Song Guo, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Induced CD4+ forkhead box protein–positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1</title><author>Su, Wenru, MD ; Fan, Huimin, MD, PhD ; Chen, Maogen, MD ; Wang, Julie, BS ; Brand, David, PhD ; He, Xiaoshun, MD, PhD ; Quesniaux, Valerie, PhD ; Ryffel, Bernhard, MD, PhD ; Zhu, Ling, PhD ; Liang, Dan, MD, PhD ; Zheng, Song Guo, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6a8f6a0cff369022af83f2fe2f3fd1aa22a6706a2c71136c498e04500b5ca1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>allergic</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Communication - immunology</topic><topic>Coculture Techniques</topic><topic>contact hypersensitivity</topic><topic>Dermatitis, Contact - immunology</topic><topic>Dermatitis, Contact - pathology</topic><topic>Dermatitis, Contact - therapy</topic><topic>Diffusion Chambers, Culture</topic><topic>Disease Models, Animal</topic><topic>Forkhead Transcription Factors - biosynthesis</topic><topic>Forkhead Transcription Factors - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>induced regulatory T cells</topic><topic>Lymphocyte Activation</topic><topic>Lymphocyte Transfusion</topic><topic>Mast cells</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>NF-kappa B - genetics</topic><topic>NF-kappa B - immunology</topic><topic>RNA, Small Interfering - genetics</topic><topic>RNA, Small Interfering - immunology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Signal Transduction - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - metabolism</topic><topic>TGF-β</topic><topic>Transforming Growth Factor beta1 - antagonists &amp; inhibitors</topic><topic>Transforming Growth Factor beta1 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Wenru, MD</creatorcontrib><creatorcontrib>Fan, Huimin, MD, PhD</creatorcontrib><creatorcontrib>Chen, Maogen, MD</creatorcontrib><creatorcontrib>Wang, Julie, BS</creatorcontrib><creatorcontrib>Brand, David, PhD</creatorcontrib><creatorcontrib>He, Xiaoshun, MD, PhD</creatorcontrib><creatorcontrib>Quesniaux, Valerie, PhD</creatorcontrib><creatorcontrib>Ryffel, Bernhard, MD, PhD</creatorcontrib><creatorcontrib>Zhu, Ling, PhD</creatorcontrib><creatorcontrib>Liang, Dan, MD, PhD</creatorcontrib><creatorcontrib>Zheng, Song Guo, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Wenru, MD</au><au>Fan, Huimin, MD, PhD</au><au>Chen, Maogen, MD</au><au>Wang, Julie, BS</au><au>Brand, David, PhD</au><au>He, Xiaoshun, MD, PhD</au><au>Quesniaux, Valerie, PhD</au><au>Ryffel, Bernhard, MD, PhD</au><au>Zhu, Ling, PhD</au><au>Liang, Dan, MD, PhD</au><au>Zheng, Song Guo, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induced CD4+ forkhead box protein–positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2012-08</date><risdate>2012</risdate><volume>130</volume><issue>2</issue><spage>444</spage><epage>452.e7</epage><pages>444-452.e7</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Induced CD4+ forkhead box protein 3–positve regulatory T (iTreg) cells are a promising source for cell-based therapies of established inflammatory and autoimmune diseases. However, their relationship to mast cell (MC) function and MC-driven diseases remains unknown. Objective We sought to explore the roles of iTreg cells on MC function and the established MC-driven disease contact hypersensitivity (CHS). Methods In vitro coculture studies were carried out to investigate the interaction between iTreg cells in murine or human MCs by using both direct cell-cell contact and transwell systems to separate cell-cell contact. In vivo mice iTreg cells were administered to mice with established CHS, and innate immunologic responses, such as MC infiltration and inflammatory cytokine expression at contact sites, were evaluated. Results In vitro coculture under direct cell-cell contact resulted in indirect suppression of IgE-independent activation of MCs by murine or human iTreg cells. Mechanistically, iTreg cells suppressed proinflammatory cytokine levels by modulating nuclear factor κB p65 activation in MCs through T cell–derived TGF-β1. Injection of iTreg cells but not natural CD4+ CD25+ regulatory T cells into animals with established CHS resulted in the suppression of infiltration and functions of MCs and also led to decreased production of inflammatory cytokines at allergic contact areas. iTreg cell–mediated immunosuppressive effects were abrogated when iTreg cells were pretreated with TGF-β1 small interfering RNA. Conclusions Our study demonstrates that iTreg cells suppress MC function and attenuate established MC-driven CHS through TGF-β1–dependent mechanisms.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22738679</pmid><doi>10.1016/j.jaci.2012.05.011</doi><tpages>9</tpages></addata></record>
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source Elsevier
subjects allergic
Allergy and Immunology
Animals
Antigens, CD - genetics
Antigens, CD - immunology
Biological and medical sciences
Cell Communication - immunology
Coculture Techniques
contact hypersensitivity
Dermatitis, Contact - immunology
Dermatitis, Contact - pathology
Dermatitis, Contact - therapy
Diffusion Chambers, Culture
Disease Models, Animal
Forkhead Transcription Factors - biosynthesis
Forkhead Transcription Factors - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
induced regulatory T cells
Lymphocyte Activation
Lymphocyte Transfusion
Mast cells
Mast Cells - immunology
Mast Cells - metabolism
Medical sciences
Mice
Mice, Inbred BALB C
NF-kappa B - genetics
NF-kappa B - immunology
RNA, Small Interfering - genetics
RNA, Small Interfering - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Signal Transduction - immunology
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
TGF-β
Transforming Growth Factor beta1 - antagonists & inhibitors
Transforming Growth Factor beta1 - immunology
title Induced CD4+ forkhead box protein–positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1
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