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Dosimetric study of the different techniques to deal with respiratory motion for lung stereotactic radiotherapy
To evaluate the different respiratory movement management techniques during irradiation of lung tumours. Seven patients with one or more primary or secondary lung lesions less than 5 cm (11 tumours in total) had three computed tomographies (CT): free-breathing, deep-inspiration breath-hold using a s...
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| Published in: | Cancer radiothérapie 2012-07, Vol.16 (4), p.263-271 |
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| container_end_page | 271 |
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| container_title | Cancer radiothérapie |
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| creator | Paumier, A Crespeau, A Krhili, S Georgin-Mège, M Tuchais, C Mesgouez, J Cellier, P Lisbona, A Denis, F Autret, D |
| description | To evaluate the different respiratory movement management techniques during irradiation of lung tumours.
Seven patients with one or more primary or secondary lung lesions less than 5 cm (11 tumours in total) had three computed tomographies (CT): free-breathing, deep-inspiration breath-hold using a spirometer, and 4-dimensional (4D). From these three acquisitions, five treatment plans were performed: free-breathing (reference method), deep-inspiration breath-hold, and three from the 4D CT: two breathing synchronized treatments (inspiration and expiration) and one treatment taking into account all the tumour motions (definition of the internal target volume [ITV]). Planning target volume (PTV) size and dose delivered to the lungs were compared.
Mean PTV with the free-breathing modality was 83 ± 28 cm(3), which was significantly greater than any of the other techniques (P |
| doi_str_mv | 10.1016/j.canrad.2012.03.004 |
| format | article |
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Seven patients with one or more primary or secondary lung lesions less than 5 cm (11 tumours in total) had three computed tomographies (CT): free-breathing, deep-inspiration breath-hold using a spirometer, and 4-dimensional (4D). From these three acquisitions, five treatment plans were performed: free-breathing (reference method), deep-inspiration breath-hold, and three from the 4D CT: two breathing synchronized treatments (inspiration and expiration) and one treatment taking into account all the tumour motions (definition of the internal target volume [ITV]). Planning target volume (PTV) size and dose delivered to the lungs were compared.
Mean PTV with the free-breathing modality was 83 ± 28 cm(3), which was significantly greater than any of the other techniques (P<0.0001). Compared to the free-breathing PTV, PTV defined with the ITV was reduced by one quarter (63 ± 31 cm(3)), and PTV with the deep-inspiration breath-hold, breathing synchronized inspiration and breathing synchronized expiration techniques were reduced by one third (50 to 54 ± 24 to 26 cm(3)). Deep-inspiration led to significantly increase the healthy lung volume compared to other methods (mean volume of 5500 ± 1500 cm(3) versus 3540 to 3920 cm(3), respectively, P<0.0001). The volume of healthy lungs receiving at least 5 and 20 Gy (V5 and V5) were significantly higher with the free-breathing method than any of the other methods (P<0.0001). The deep-inspiration breath-hold modality led to the lowest lung V5 and V20.
Deep-inspiration breath-hold technique provides the most significant dosimetric advantages: small PTV and large lung volume. However, patients must be able to hold 20 seconds of apnea. Respiratory gating also reduces the PTV, but its application often requires the implantation of fiducial, which limit its use. A 4-dimensional CT allows for a personalized and reduced PTV compared to free-breathing CT.</description><identifier>EISSN: 1769-6658</identifier><identifier>DOI: 10.1016/j.canrad.2012.03.004</identifier><identifier>PMID: 22717260</identifier><language>eng ; fre</language><publisher>France</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Lung Neoplasms - radiotherapy ; Male ; Middle Aged ; Radiotherapy - methods ; Radiotherapy Dosage ; Respiratory-Gated Imaging Techniques ; Stereotaxic Techniques</subject><ispartof>Cancer radiothérapie, 2012-07, Vol.16 (4), p.263-271</ispartof><rights>Copyright © 2012 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22717260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paumier, A</creatorcontrib><creatorcontrib>Crespeau, A</creatorcontrib><creatorcontrib>Krhili, S</creatorcontrib><creatorcontrib>Georgin-Mège, M</creatorcontrib><creatorcontrib>Tuchais, C</creatorcontrib><creatorcontrib>Mesgouez, J</creatorcontrib><creatorcontrib>Cellier, P</creatorcontrib><creatorcontrib>Lisbona, A</creatorcontrib><creatorcontrib>Denis, F</creatorcontrib><creatorcontrib>Autret, D</creatorcontrib><title>Dosimetric study of the different techniques to deal with respiratory motion for lung stereotactic radiotherapy</title><title>Cancer radiothérapie</title><addtitle>Cancer Radiother</addtitle><description>To evaluate the different respiratory movement management techniques during irradiation of lung tumours.
Seven patients with one or more primary or secondary lung lesions less than 5 cm (11 tumours in total) had three computed tomographies (CT): free-breathing, deep-inspiration breath-hold using a spirometer, and 4-dimensional (4D). From these three acquisitions, five treatment plans were performed: free-breathing (reference method), deep-inspiration breath-hold, and three from the 4D CT: two breathing synchronized treatments (inspiration and expiration) and one treatment taking into account all the tumour motions (definition of the internal target volume [ITV]). Planning target volume (PTV) size and dose delivered to the lungs were compared.
Mean PTV with the free-breathing modality was 83 ± 28 cm(3), which was significantly greater than any of the other techniques (P<0.0001). Compared to the free-breathing PTV, PTV defined with the ITV was reduced by one quarter (63 ± 31 cm(3)), and PTV with the deep-inspiration breath-hold, breathing synchronized inspiration and breathing synchronized expiration techniques were reduced by one third (50 to 54 ± 24 to 26 cm(3)). Deep-inspiration led to significantly increase the healthy lung volume compared to other methods (mean volume of 5500 ± 1500 cm(3) versus 3540 to 3920 cm(3), respectively, P<0.0001). The volume of healthy lungs receiving at least 5 and 20 Gy (V5 and V5) were significantly higher with the free-breathing method than any of the other methods (P<0.0001). The deep-inspiration breath-hold modality led to the lowest lung V5 and V20.
Deep-inspiration breath-hold technique provides the most significant dosimetric advantages: small PTV and large lung volume. However, patients must be able to hold 20 seconds of apnea. Respiratory gating also reduces the PTV, but its application often requires the implantation of fiducial, which limit its use. A 4-dimensional CT allows for a personalized and reduced PTV compared to free-breathing CT.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiotherapy - methods</subject><subject>Radiotherapy Dosage</subject><subject>Respiratory-Gated Imaging Techniques</subject><subject>Stereotaxic Techniques</subject><issn>1769-6658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNo1kMtOwzAURC0kREvhDxDykk2Dr5047hKVp1SJTfeRY99QV0kcbEcof08qymo2Z45GQ8gdsAwYyMdjZnQftM04A54xkTGWX5AllHKzlrJQC3Id45ExJuWmuCILzksouWRL4p99dB2m4AyNabQT9Q1NB6TWNQ0G7BNNaA69-x4x0uSpRd3SH5cONGAcXNDJh4l2Pjnf08YH2o7916yauz5pk2bvPMz52Rn0MN2Qy0a3EW_PuSL715f99n29-3z72D7t1gPkkNbFpiikwbLOQVkQCAjccuB1Ucq8xtIoa1XdQG1lY2pltEIjGYKSQqPKxYo8_GmH4E_LU9W5aLBtdY9-jBUwASCZECf0_oyOdYe2GoLrdJiq_4_ELxiobAE</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Paumier, A</creator><creator>Crespeau, A</creator><creator>Krhili, S</creator><creator>Georgin-Mège, M</creator><creator>Tuchais, C</creator><creator>Mesgouez, J</creator><creator>Cellier, P</creator><creator>Lisbona, A</creator><creator>Denis, F</creator><creator>Autret, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Dosimetric study of the different techniques to deal with respiratory motion for lung stereotactic radiotherapy</title><author>Paumier, A ; Crespeau, A ; Krhili, S ; Georgin-Mège, M ; Tuchais, C ; Mesgouez, J ; Cellier, P ; Lisbona, A ; Denis, F ; Autret, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-59556ce7b418d13e1e12d212b5764be7c8dd8bf1bd6fcb8ca8ec60e1863ae843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; fre</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiotherapy - methods</topic><topic>Radiotherapy Dosage</topic><topic>Respiratory-Gated Imaging Techniques</topic><topic>Stereotaxic Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paumier, A</creatorcontrib><creatorcontrib>Crespeau, A</creatorcontrib><creatorcontrib>Krhili, S</creatorcontrib><creatorcontrib>Georgin-Mège, M</creatorcontrib><creatorcontrib>Tuchais, C</creatorcontrib><creatorcontrib>Mesgouez, J</creatorcontrib><creatorcontrib>Cellier, P</creatorcontrib><creatorcontrib>Lisbona, A</creatorcontrib><creatorcontrib>Denis, F</creatorcontrib><creatorcontrib>Autret, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer radiothérapie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paumier, A</au><au>Crespeau, A</au><au>Krhili, S</au><au>Georgin-Mège, M</au><au>Tuchais, C</au><au>Mesgouez, J</au><au>Cellier, P</au><au>Lisbona, A</au><au>Denis, F</au><au>Autret, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric study of the different techniques to deal with respiratory motion for lung stereotactic radiotherapy</atitle><jtitle>Cancer radiothérapie</jtitle><addtitle>Cancer Radiother</addtitle><date>2012-07</date><risdate>2012</risdate><volume>16</volume><issue>4</issue><spage>263</spage><epage>271</epage><pages>263-271</pages><eissn>1769-6658</eissn><abstract>To evaluate the different respiratory movement management techniques during irradiation of lung tumours.
Seven patients with one or more primary or secondary lung lesions less than 5 cm (11 tumours in total) had three computed tomographies (CT): free-breathing, deep-inspiration breath-hold using a spirometer, and 4-dimensional (4D). From these three acquisitions, five treatment plans were performed: free-breathing (reference method), deep-inspiration breath-hold, and three from the 4D CT: two breathing synchronized treatments (inspiration and expiration) and one treatment taking into account all the tumour motions (definition of the internal target volume [ITV]). Planning target volume (PTV) size and dose delivered to the lungs were compared.
Mean PTV with the free-breathing modality was 83 ± 28 cm(3), which was significantly greater than any of the other techniques (P<0.0001). Compared to the free-breathing PTV, PTV defined with the ITV was reduced by one quarter (63 ± 31 cm(3)), and PTV with the deep-inspiration breath-hold, breathing synchronized inspiration and breathing synchronized expiration techniques were reduced by one third (50 to 54 ± 24 to 26 cm(3)). Deep-inspiration led to significantly increase the healthy lung volume compared to other methods (mean volume of 5500 ± 1500 cm(3) versus 3540 to 3920 cm(3), respectively, P<0.0001). The volume of healthy lungs receiving at least 5 and 20 Gy (V5 and V5) were significantly higher with the free-breathing method than any of the other methods (P<0.0001). The deep-inspiration breath-hold modality led to the lowest lung V5 and V20.
Deep-inspiration breath-hold technique provides the most significant dosimetric advantages: small PTV and large lung volume. However, patients must be able to hold 20 seconds of apnea. Respiratory gating also reduces the PTV, but its application often requires the implantation of fiducial, which limit its use. A 4-dimensional CT allows for a personalized and reduced PTV compared to free-breathing CT.</abstract><cop>France</cop><pmid>22717260</pmid><doi>10.1016/j.canrad.2012.03.004</doi><tpages>9</tpages></addata></record> |
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| language | eng ; fre |
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| subjects | Adult Aged Aged, 80 and over Female Humans Lung Neoplasms - radiotherapy Male Middle Aged Radiotherapy - methods Radiotherapy Dosage Respiratory-Gated Imaging Techniques Stereotaxic Techniques |
| title | Dosimetric study of the different techniques to deal with respiratory motion for lung stereotactic radiotherapy |
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